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From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease
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SYSNO ASEP 0025479 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease Title Od nepeptidových k neuhlíkatým inhibitorům proteas: metallakarborany jako specifické a účinné inhibitory HIV proteasy Author(s) Cígler, Petr (UOCHB-X) RID, ORCID
Kožíšek, Milan (UOCHB-X) RID, ORCID
Řezáčová, Pavlína (UMG-J) RID
Brynda, Jiří (UMG-J) RID
Otwinowski, Z. (US)
Pokorná, Jana (UOCHB-X) RID
Plešek, Jaromír (UACH-T)
Grüner, Bohumír (UACH-T) RID, SAI, ORCID
Marešová, Lucie (UOCHB-X) RID
Máša, Martin (UOCHB-X)
Sedláček, Juraj (UMG-J) RID
Bodem, J. (DE)
Kräusslich, H. G. (DE)
Král, V. (CZ)
Konvalinka, Jan (UOCHB-X) RID, ORCIDSource Title Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424
Roč. 102, č. 43 (2005), s. 15394-15399Number of pages 6 s. Language eng - English Country US - United States Keywords carboranes ; HIV protease ; X-ray structure Subject RIV CE - Biochemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LC523 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) AV0Z40320502 - UACH-T (2005-2011) Annotation Metallacarboranes, polyhedral cobalt -containing compounds are specific and potent inhbitors of HIV protease. There are non toxic to the cells and do not significantly inhibit other enzymes. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2006
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