0025098 - FGÚ 2006 RIV CZ eng J - Journal Article
Tribulová, N. - Dupont, E. - Soukup, Tomáš - Okruhlicová, L. - Severs, N. J.
Sex differences in connexin-43 expression in left ventricles of aging rats.
[Pohlavní rozdíly v obsahu connexinu-43 v levé komoře starých potkanů.]
Physiological Research. Roč. 54, č. 6 (2005), s. 705-708. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA304/05/0327
Grant - others:MYORES(XE) 511978; CZ-SK(CZ) 02-2004-05
Institutional research plan: CEZ:AV0Z50110509
Keywords : connexin-43 * rat cardiomyocytes * male and female specificity
Subject RIV: ED - Physiology
Impact factor: 1.806, year: 2005

We have found no significant differences in Cx43 expression and phosphorylation between T4-treated and control untreated animals. However, expression of Cx43 was significantly higher in female compared to male rats. We conclude that T4 administration has no effect on Cx43 expression, but there are sex-dependent differences in Cx43 expression in the left ventricles between aging male and female rats. This can contribute to the higher resistance of females to heart damage

Zatímco aplikace tyroxinu neměla vliv na obsah connexinu-43, exprese Cx-43 byla signifikantně vyšší u samic než u samců starých potkanů. Zjištěný nález je ve shodě s vyšší resistencí samic na srdeční poškození
Permanent Link: http://hdl.handle.net/11104/0115530