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Asparagine, valine, and threonine in the third extracellular loop of muscarinic receptor have essential roles in the positive cooperativity of strychnine-like allosteric modulators
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SYSNO ASEP 0025009 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Asparagine, valine, and threonine in the third extracellular loop of muscarinic receptor have essential roles in the positive cooperativity of strychnine-like allosteric modulators Title Asparagin, valin a threonin ve třetí extracelulární kličce muskarinového acetylcholinového receptoru mají zásadní úlohu pro pozitivní kooperativitu alosterických modulátorů podobných strychninu Author(s) Jakubík, Jan (FGU-C) RID, ORCID
Krejčí, Alena (FGU-C)
Doležal, Vladimír (FGU-C) RID, ORCIDSource Title Journal of Pharmacology and Experimental Therapeutics. - : American Society for Pharmacology and Experimental Therapeutics - ISSN 0022-3565
Roč. 313, č. 2 (2005), s. 688-696Number of pages 9 s. Language eng - English Country US - United States Keywords muscarinic receptors ; positive cooperativity ; mutation Subject RIV ED - Physiology R&D Projects GA309/02/1331 GA ČR - Czech Science Foundation (CSF) GP305/02/D090 GA ČR - Czech Science Foundation (CSF) IAA5011306 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) Annotation Exchange of only three amino acids in the third extracellular loop of muscarinic M(3) receptor for corresponding amino acids from the same loop of muscarinic M(2) receptor results in positive cooperativity between N-methylscopolamine and Wieland-Gumlich aldehyde binding in chimeric receptor. This is a new phenotype that does not occur at any native subtype of muscarinic receptors Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2006
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