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Chronic treatment with amyloid beta(1-42) inhibits non-cholinergic high-affinity choline transport in NG108-15 cells through protein kinase C signaling
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SYSNO ASEP 0025001 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Chronic treatment with amyloid beta(1-42) inhibits non-cholinergic high-affinity choline transport in NG108-15 cells through protein kinase C signaling Title Dlouhodobé působení amyloidu beta(1-42) inhibuje u buněk NG108-15 necholinergní vysokoafinitní transport cholinu prostřednictvím signalizace proteinové kinázy C Author(s) Nováková, Jana (FGU-C)
Mikasová, Lenka (FGU-C)
Machová, Eva (FGU-C)
Lisá, Věra (FGU-C)
Doležal, Vladimír (FGU-C) RID, ORCIDSource Title Brain Research. - : Elsevier - ISSN 0006-8993
Roč. 1062, č. 1-2 (2005), s. 101-110Number of pages 10 s. Language eng - English Country NL - Netherlands Keywords choline transporter ; beta-amyloid ; protein kinase C Subject RIV ED - Physiology R&D Projects IAA5011206 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) Annotation Prolonged treatment of NG108-15 cells with amyloid beta(1-42) induces the decrease of non-cholinergic high affinify choline transport. This inhibitory effect is prevented by protein kinase C inhibitor staurosporine. The reduction of choline transport that is used for phospholipid synthesis may play a role in the pathogenesis of Alzheimer´s disease Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2006
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