In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1-and -2-catalyzed prostaglandin E2 biosyntheses

Maršík, Petr; Kokoška, L.; Landa, P.; Nepovím, Aleš; Soudek, Petr; Vaněk, Tomáš

Number of the records: 1

In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1-and -2-catalyzed prostaglandin E2 biosyntheses

1.

SYSNO ASEP	0022309
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1-and -2-catalyzed prostaglandin E2 biosyntheses
Title	Inhibiční efekt tymolu a chinonů ze semen Nigella sativa na biosyntézu prostaglandinu E2 katalyzovanou cyklooxgenázami -1 a -2 in vitro
Author(s)	Maršík, Petr (UOCHB-X) Kokoška, L. (CZ) Landa, P. (CZ) Nepovím, Aleš (UOCHB-X) Soudek, Petr (UOCHB-X) Vaněk, Tomáš (UOCHB-X)
Source Title	Planta medica - ISSN 0032-0943 Roč. 71, - (2005), s. 739-742
Number of pages	4 s.
Language	eng - English
Country	DE - Germany
Keywords	Nigella sativa ; thymol ; thymoquinone
Subject RIV	CE - Biochemistry
R&D Projects	GA525/02/0257 GA ČR - Czech Science Foundation (CSF)
	1P04OC926.001 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
Annotation	Dithymoquinone, thymohydroquinone, thymol and thymoquinone, the compounds derived from N. sativa seeds, were investigated for their in vitro anti-inflammatory activities using cyclooxygenase-1 (COX-1) and-2 (COX-2) assays. Thymol was the most active against COX-1 with IC50 value of 0.2 .mu.M, while thymohydroquinone and thymoquinone exhibited the strongest inhibitory effect on COX-2 with IC50 values of 0.1 and 0.3 .mu.M, respectively.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2006

Number of the records: 1