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Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function and lung tumor susceptibility
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SYSNO ASEP 0000223 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function and lung tumor susceptibility Title Nové lokusy regulující proliferativní odpovědi lymfocytů na cytokiny a jejich spojení s lokusy regulujícími autoimunitní reakce, funkci makrofágů a citlivost k plicním nádorům Author(s) Lipoldová, Marie (UMG-J) RID
Havelková, Helena (UMG-J)
Badalová, Jana (UMG-J)
Demant, P. (NL)Source Title International Journal of Cancer. - : Wiley - ISSN 0020-7136
Roč. 114, č. 3 (2005), s. 394-399Number of pages 6 s. Language eng - English Country GR - Greece Keywords lymphocyte activation ; interleukin ; lung cancer susceptibility Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA310/03/1381 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5052915 - UMG-J Annotation Novel genotyping and statistical tools have led to mapping of numerous QTL loci for multigenic traits that previously could not be detected. The relationships of these QTL families to other QTL families and the functional specialization of their members can now be studied. We have mapped loci controlling activation of T lymphocytes by mitogens and cytokines and their capacity to produce cytokines (Cinda3-5). These novel Cinda loci and the previously mapped Cinda1 locus seem to be located in genomic regions together with other QTL families. The possible relevance of these QTL associations in several different sites of the genome for the immune response, inflammation and tumorigenesis has to be elucidated. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2005
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