A new role of sigma factors in regulation of bacterial transcription

Pospíšil, Jiří; Schwarz, Marek; Ziková, Alice; Vítovská, Dragana; Hradilová, Miluše; Kolář, Michal; Křenková, Alena; Hubálek, Martin; Krásný, Libor; Vohradský, Jiří

Number of the records: 1

A new role of sigma factors in regulation of bacterial transcription

1.

SYSNO ASEP	0581866
Document Type	A - Abstract
R&D Document Type	O - Ostatní
Title	A new role of sigma factors in regulation of bacterial transcription
Author(s)	Pospíšil, Jiří (MBU-M)_{ORCID, RID} Schwarz, Marek (MBU-M)_{ORCID, RID} Ziková, Alice (MBU-M) Vítovská, Dragana (MBU-M)_ORCID Hradilová, Miluše (UMG-J) Kolář, Michal (UMG-J)_{RID, ORCID} Křenková, Alena (UOCHB-X)_{ORCID, RID} Hubálek, Martin (UOCHB-X)_{RID, ORCID} Krásný, Libor (MBU-M)_{RID, ORCID} Vohradský, Jiří (MBU-M)_{RID, ORCID}
Source Title	Czech Chem. Soc. Symp. Series Roč. 21, č. 5 (2023), s. 210-210
Number of pages	1 s.
Publication form	Print - P
Action	Annual meeting of the National Institute of Virology and Bacteriology (NIVB) /2./
Event date	02.10.2023 - 05.10.2023
VEvent location	Kutná Hora
Country	CZ - Czech Republic
Event type	EUR
Language	eng - English
Country	CZ - Czech Republic
Keywords	gene expression ; sigma factors ; RNA polymerase
OECD category	Microbiology
R&D Projects	LX22NPO5103 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	MBU-M - RVO:61388971 ; UMG-J - RVO:68378050 ; UOCHB-X - RVO:61388963
Annotation	Bacterial gene expression is controlled by sigma (σ) factors, that bind to RNA polymerase (RNAP), recognize specific promoter sequences in DNA, and mediate transcription initiation. Bacteria always contain one primary or so called “housekeeping” σ factor. In the gram-positive antibiotic producing bacterium, Streptomyces coelicolor, 65 genes encoding different σ factors are found. HrdB is the main sigma factor in S. coelicolor and is responsible for expression of essential genes. On the other hand, genes that are required in different stresses or environmental conditions are regulated by alternative σ factors. Alternative σ factors are typically about half the size (~30 kDa) of HrdB and lack some of its domains. These factors recognize promoter consensus sequences different from HrdB. They are responsible for transcription of gene subsets with specific functions1,2
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2024

Number of the records: 1