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Feeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice

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    SYSNO ASEP0575555
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleFeeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice
    Author(s) Mengr, Anna (UOCHB-X)
    Strnadová, Veronika (UOCHB-X)
    Strnad, Štěpán (UOCHB-X) ORCID
    Vrkoslav, Vladimír (UOCHB-X) RID, ORCID
    Pelantová, Helena (MBU-M) ORCID, RID
    Kuzma, Marek (MBU-M) ORCID, RID
    Comptdaer, T. (FR)
    Železná, Blanka (UOCHB-X) RID, ORCID
    Kuneš, Jaroslav (UOCHB-X) ORCID, RID
    Galas, M. C. (FR)
    Pačesová, Andrea (UOCHB-X) ORCID
    Maletínská, Lenka (UOCHB-X) RID, ORCID
    Article number3690
    Source TitleNutrients. - : MDPI
    Roč. 15, č. 17 (2023)
    Number of pages27 s.
    Languageeng - English
    CountryCH - Switzerland
    Keywordsinsulin resistance ; glucose intolerance ; inflammation ; neuroinflammation ; obesity ; Alzheimer’s disease ; amyloid-β ; tau protein ; APP/PS1
    OECD categoryPhysiology (including cytology)
    R&D ProjectsGA20-00546S GA ČR - Czech Science Foundation (CSF)
    TN01000013 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
    LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    EF18_053/0016940 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Research InfrastructureCCP II - 90126 - Ústav molekulární genetiky AV ČR, v. v. i.
    Method of publishingOpen access
    Institutional supportUOCHB-X - RVO:61388963 ; MBU-M - RVO:61388971
    UT WOS001064160100001
    EID SCOPUS85170208754
    DOI10.3390/nu15173690
    AnnotationAlzheimer’s disease (AD) is a progressive brain disorder characterized by extracellular amyloid-β (Aβ) plaques, intracellular neurofibrillary tangles formed by hyperphosphorylated Tau protein and neuroinflammation. Previous research has shown that obesity and type 2 diabetes mellitus, underlined by insulin resistance (IR), are risk factors for neurodegenerative disorders. In this study, obesity-induced peripheral and central IR and inflammation were studied in relation to AD-like pathology in the brains and periphery of APP/PS1 mice, a model of Aβ pathology, fed a high-fat diet (HFD). APP/PS1 mice and their wild-type controls fed either a standard diet or HFD were characterized at the ages of 3, 6 and 10 months by metabolic parameters related to obesity via mass spectroscopy, nuclear magnetic resonance, immunoblotting and immunohistochemistry to quantify how obesity affected AD pathology. The HFD induced substantial peripheral IR leading to central IR. APP/PS1-fed HFD mice had more pronounced IR, glucose intolerance and liver steatosis than their WT controls. The HFD worsened Aβ pathology in the hippocampi of APP/PS1 mice and significantly supported both peripheral and central inflammation. This study reveals a deleterious effect of obesity-related mild peripheral inflammation and prediabetes on the development of Aβ and Tau pathology and neuroinflammation in APP/PS1 mice.
    WorkplaceInstitute of Organic Chemistry and Biochemistry
    Contactasep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
    Year of Publishing2024
    Electronic addresshttps://doi.org/10.3390/nu15173690
Number of the records: 1  

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