Feeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice

Mengr, Anna; Strnadová, Veronika; Strnad, Štěpán; Vrkoslav, Vladimír; Pelantová, Helena; Kuzma, Marek; Comptdaer, T.; Železná, Blanka; Kuneš, Jaroslav; Galas, M. C.; Pačesová, Andrea; Maletínská, Lenka

doi:https://dx.doi.org/10.3390/nu15173690

Number of the records: 1

Feeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice

1.

SYSNO ASEP	0575555
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Feeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice
Author(s)	Mengr, Anna (UOCHB-X) Strnadová, Veronika (UOCHB-X) Strnad, Štěpán (UOCHB-X)_ORCID Vrkoslav, Vladimír (UOCHB-X)_{RID, ORCID} Pelantová, Helena (MBU-M)_{ORCID, RID} Kuzma, Marek (MBU-M)_{ORCID, RID} Comptdaer, T. (FR) Železná, Blanka (UOCHB-X)_{RID, ORCID} Kuneš, Jaroslav (UOCHB-X)_{ORCID, RID} Galas, M. C. (FR) Pačesová, Andrea (UOCHB-X)_ORCID Maletínská, Lenka (UOCHB-X)_{RID, ORCID}
Article number	3690
Source Title	Nutrients. - : MDPI Roč. 15, č. 17 (2023)
Number of pages	27 s.
Language	eng - English
Country	CH - Switzerland
Keywords	insulin resistance ; glucose intolerance ; inflammation ; neuroinflammation ; obesity ; Alzheimer’s disease ; amyloid-β ; tau protein ; APP/PS1
OECD category	Physiology (including cytology)
R&D Projects	GA20-00546S GA ČR - Czech Science Foundation (CSF)
	TN01000013 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
	LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	EF18_053/0016940 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Research Infrastructure	CCP II - 90126 - Ústav molekulární genetiky AV ČR, v. v. i.
Method of publishing	Open access
Institutional support	UOCHB-X - RVO:61388963 ; MBU-M - RVO:61388971
UT WOS	001064160100001
EID SCOPUS	85170208754
DOI	10.3390/nu15173690
Annotation	Alzheimer’s disease (AD) is a progressive brain disorder characterized by extracellular amyloid-β (Aβ) plaques, intracellular neurofibrillary tangles formed by hyperphosphorylated Tau protein and neuroinflammation. Previous research has shown that obesity and type 2 diabetes mellitus, underlined by insulin resistance (IR), are risk factors for neurodegenerative disorders. In this study, obesity-induced peripheral and central IR and inflammation were studied in relation to AD-like pathology in the brains and periphery of APP/PS1 mice, a model of Aβ pathology, fed a high-fat diet (HFD). APP/PS1 mice and their wild-type controls fed either a standard diet or HFD were characterized at the ages of 3, 6 and 10 months by metabolic parameters related to obesity via mass spectroscopy, nuclear magnetic resonance, immunoblotting and immunohistochemistry to quantify how obesity affected AD pathology. The HFD induced substantial peripheral IR leading to central IR. APP/PS1-fed HFD mice had more pronounced IR, glucose intolerance and liver steatosis than their WT controls. The HFD worsened Aβ pathology in the hippocampi of APP/PS1 mice and significantly supported both peripheral and central inflammation. This study reveals a deleterious effect of obesity-related mild peripheral inflammation and prediabetes on the development of Aβ and Tau pathology and neuroinflammation in APP/PS1 mice.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2024
Electronic address	https://doi.org/10.3390/nu15173690

Number of the records: 1