Multifunctional Oxidized Dextran as a Matrix for Stabilization of Octahedral Molybdenum and Tungsten Iodide Clusters in Aqueous Media

0573611 - ÚACH 2024 RIV CH eng J - Journal Article
Pronina, E. V. - Vorotnikov, Y. A. - Pozmogova, T.N. - Tsygankova, A. R. - Kirakci, Kaplan - Lang, Kamil - Shestopalov, M.A.
Multifunctional Oxidized Dextran as a Matrix for Stabilization of Octahedral Molybdenum and Tungsten Iodide Clusters in Aqueous Media.
International Journal of Molecular Sciences. Roč. 24, č. 12 (2023), č. článku 10010. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA21-11688S
Institutional support: RVO:61388980
Keywords : cytotoxicity * hydrolysis * luminescence * molybdenum * octahedral iodide cluster * oxidized dextran polysaccharide * photodynamic therapy * stability * tungsten
OECD category: Inorganic and nuclear chemistry
Impact factor: 5.6, year: 2022
Method of publishing: Open access

Due to their high abundance, polymeric character, and chemical tunability, polysaccharides are perfect candidates for the stabilization of photoactive nanoscale objects, which are of great interest in modern science but can be unstable in aqueous media. In this work, we have demonstrated the relevance of oxidized dextran polysaccharide, obtained via a simple reaction with H2O2, towards the stabilization of photoactive octahedral molybdenum and tungsten iodide cluster complexes [M6I8}(DMSO)6](NO3)4 in aqueous and culture media. The cluster-containing materials were obtained by co-precipitation of the starting reagents in DMSO solution. According to the data obtained, the amount and ratio of functional carbonyl and carboxylic groups as well as the molecular weight of oxidized dextran strongly affect the extent of stabilization, i.e., high loading of aldehyde groups and high molecular weight increase the stability, while acidic groups have some negative impact on the stability. The most stable material based on the tungsten cluster complex exhibited low dark and moderate photoinduced cytotoxicity, which together with high cellular uptake makes these polymers promising for the fields of bioimaging and PDT.
Permanent Link: https://hdl.handle.net/11104/0344013