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Advanced micro- & nanostructuring for enhanced biocompatibility of stainless steel by multi-beam and beamshaping technology
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SYSNO ASEP 0572404 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Advanced micro- & nanostructuring for enhanced biocompatibility of stainless steel by multi-beam and beamshaping technology Author(s) Hauschwitz, Petr (FZU-D) ORCID
Klíčová, M. (CZ)
Mullerová, S. (CZ)
Bičišťová, Radka (FZU-D) ORCID
Procházka, Martin (FZU-D)
Brajer, Jan (FZU-D) ORCID
Chyla, Michal (FZU-D) RID, ORCID
Smrž, Martin (FZU-D) RID, ORCID
Chvojka, J. (CZ)
Mocek, Tomáš (FZU-D) RID, ORCID, SAINumber of authors 10 Article number 045008 Source Title Biomedical Materials. - : Institute of Physics Publishing - ISSN 1748-6041
Roč. 18, č. 4 (2023)Number of pages 9 s. Language eng - English Country US - United States Keywords biocompatibility ; lipss ; nanostructuring ; beamshaping ; cell proliferation Subject RIV BH - Optics, Masers, Lasers OECD category Optics (including laser optics and quantum optics) R&D Projects EF15_006/0000674 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FZU-D - RVO:68378271 UT WOS 000989690300001 EID SCOPUS 85159740683 DOI 10.1088/1748-605X/acd291 Annotation Biocompatibility is one of the key issues for implants, especially in the case of stainless steel with medium to low biocompatibility, which may lead to a lack of osseointegration and consequently to implant failure or rejection. To precisely control preferential cell growth sites and, consequently, the biocompatibility of prosthetic devices, two types of surfaces were analyzed, containing periodic nanogrooves laser induced periodic surface structure (LIPSS) and square-shaped micropillars. For the fast and efficient production of these surfaces, the unique combination of high energy ultrashort pulsed laser system with multi-beam and beamshaping technology was applied, resulting in increased productivity by 526% for micropillars and 14 570% for LIPSS compared to single beam methods. In vitro analysis revealed that micro and nanostructured surfaces provide a better environment for cell attachment and proliferation compared to untreated ones, showing an increase of up to 496% in the number of cells compared to the reference. Moreover, the combination of LIPSS and micropillars resulted in a precise cell orientation along the periodic microgroove pattern. The combination of these results demonstrates the possibility of mass production of functionalized implants with control over cell organization and growth. Thus, reducing the risk of implant failure due to low biocompatibility.
Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2024 Electronic address https://hdl.handle.net/11104/0349449
Number of the records: 1