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Advanced micro- & nanostructuring for enhanced biocompatibility of stainless steel by multi-beam and beamshaping technology

  1. 1.
    SYSNO ASEP0572404
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleAdvanced micro- & nanostructuring for enhanced biocompatibility of stainless steel by multi-beam and beamshaping technology
    Author(s) Hauschwitz, Petr (FZU-D) ORCID
    Klíčová, M. (CZ)
    Mullerová, S. (CZ)
    Bičišťová, Radka (FZU-D) ORCID
    Procházka, Martin (FZU-D)
    Brajer, Jan (FZU-D) ORCID
    Chyla, Michal (FZU-D) RID, ORCID
    Smrž, Martin (FZU-D) RID, ORCID
    Chvojka, J. (CZ)
    Mocek, Tomáš (FZU-D) RID, ORCID, SAI
    Number of authors10
    Article number045008
    Source TitleBiomedical Materials. - : Institute of Physics Publishing - ISSN 1748-6041
    Roč. 18, č. 4 (2023)
    Number of pages9 s.
    Languageeng - English
    CountryUS - United States
    Keywordsbiocompatibility ; lipss ; nanostructuring ; beamshaping ; cell proliferation
    Subject RIVBH - Optics, Masers, Lasers
    OECD categoryOptics (including laser optics and quantum optics)
    R&D ProjectsEF15_006/0000674 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Method of publishingOpen access
    Institutional supportFZU-D - RVO:68378271
    UT WOS000989690300001
    EID SCOPUS85159740683
    DOI10.1088/1748-605X/acd291
    AnnotationBiocompatibility is one of the key issues for implants, especially in the case of stainless steel with medium to low biocompatibility, which may lead to a lack of osseointegration and consequently to implant failure or rejection. To precisely control preferential cell growth sites and, consequently, the biocompatibility of prosthetic devices, two types of surfaces were analyzed, containing periodic nanogrooves laser induced periodic surface structure (LIPSS) and square-shaped micropillars. For the fast and efficient production of these surfaces, the unique combination of high energy ultrashort pulsed laser system with multi-beam and beamshaping technology was applied, resulting in increased productivity by 526% for micropillars and 14 570% for LIPSS compared to single beam methods. In vitro analysis revealed that micro and nanostructured surfaces provide a better environment for cell attachment and proliferation compared to untreated ones, showing an increase of up to 496% in the number of cells compared to the reference. Moreover, the combination of LIPSS and micropillars resulted in a precise cell orientation along the periodic microgroove pattern. The combination of these results demonstrates the possibility of mass production of functionalized implants with control over cell organization and growth. Thus, reducing the risk of implant failure due to low biocompatibility.
    WorkplaceInstitute of Physics
    ContactKristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
    Year of Publishing2024
    Electronic addresshttps://hdl.handle.net/11104/0349449
Number of the records: 1  

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