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Microglia-mediated degradation of perineuronal nets promotes pain
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SYSNO ASEP 0566878 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Microglia-mediated degradation of perineuronal nets promotes pain Author(s) Tansley, S. (CA)
Gu, N. (CA)
Guzman, A.U. (CA)
Cai, W. (CA)
Wong, C. (CA)
Lister, K.C. (CA)
Munoz-Pino, E. (CA)
Yousefpour, N. (CA)
Roome, R.B. (CA)
Heal, J. (CA)
Wu, N. (CA)
Castonguay, A. (CA)
Lean, G. (CA)
Muir, E.M. (GB)
Kania, A. (CA)
Prager-Khoutorsky, M. (CA)
Zhang, J. (CA)
Gkogkas, Ch.G. (GR)
Fawcett, James (UEM-P) ORCID
Diatchenko, L. (CA)
Ribeiro-da-Silva, A. (CA)
De Koninck, Y. (CA)
Mogil, J.S. (CA)
Khoutorsky, A. (CA)Source Title Science. - : American Association for the Advancement of Science - ISSN 0036-8075
Roč. 377, č. 6601 (2022), s. 80-86Number of pages 7 s. Language eng - English Country US - United States Keywords spared nerve injury ; spinal-cord ; neuropathic pain ; chondroitinase ABC OECD category Neurosciences (including psychophysiology Method of publishing Limited access Institutional support UEM-P - RVO:68378041 UT WOS 000822009800046 EID SCOPUS 85133903131 DOI 10.1126/science.abl6773 Annotation Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets ( PNNs), in lamina I of the spinal cord dorsal horn. Lamina I PNNs selectively enwrap spinoparabrachial projection neurons, which integrate nociceptive information in the spinal cord and convey it to supraspinal brain regions to induce pain sensation. Degradation of PNNs by microglia enhances the activity of projection neurons and induces pain-related behaviors. Thus, nerve injury-induced degradation of PNNs is a mechanism by which microglia selectively augment the output of spinal nociceptive circuits and cause pain hypersensitivity. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2023 Electronic address https://www.science.org/doi/10.1126/science.abl6773
Number of the records: 1