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Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells
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SYSNO ASEP 0566015 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells Author(s) Ryšánek, David (UMG-J)
Vašicová, Pavla (UMG-J)
Kolla, Jayaprakash Narayana (UMG-J)
Sedlák, David (UMG-J) RID
Anděra, Ladislav (UMG-J) RID
Bártek, Jiří (UMG-J) RID
Hodný, Zdeněk (UMG-J) RIDNumber of authors 7 Source Title Aging. - : Impact Journals LLC - ISSN 1945-4589
Roč. 14, č. 16 (2022), s. 6381-6414Number of pages 34 s. Publication form Online - E Language eng - English Country US - United States Keywords homoharringtonine ; cellular senescence ; bcl-2 ; mcl-1 ; senolytics Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects LM2018129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF18_046/0016045 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA18-14259S GA ČR - Czech Science Foundation (CSF) LM2018130 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000877374200002 DOI 10.18632/aging.204207 Annotation Accumulation of senescent cells in tissues with advancing age participates in the pathogenesis of several human age-associated diseases. Specific senescent secretome, the resistance of senescent cells to apoptotic stimuli, and lack of immune system response contribute to the accumulation of senescent cells and their adverse effects in tissues. Inhibition of antiapoptotic machinery, augmented in senescent cells, by BCL-2 protein family inhibitors represents a promising approach to eliminate senescent cells from tissues. This study aimed to explore synergistic and selective senolytic effects of anti-apoptotic BCL-2 family targeting compounds, particularly BH3 mimetics. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2023 Electronic address https://www.aging-us.com/article/204207/text
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