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COMIRESTROKE - A clinical study protocol for monitoring clinical effect and molecular biological readouts of COMprehensive Intensive REhabilitation program after STROKE: A four-arm parallel-group randomized double blinded controlled trial with a longitudinal design
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SYSNO ASEP 0565517 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title COMIRESTROKE - A clinical study protocol for monitoring clinical effect and molecular biological readouts of COMprehensive Intensive REhabilitation program after STROKE: A four-arm parallel-group randomized double blinded controlled trial with a longitudinal design Author(s) Řasová, K. (CZ)
Martinková, Patrícia (UIVT-O) SAI, RID, ORCID
Vařejková, Michaela (UIVT-O)
Miznerová, B. (CZ)
Pavlíková, M. (CZ)
Hlinovská, J. (CZ)
Hlinovský, D. (CZ)
Philippová, Š. (CZ)
Novotný, M. (CZ)
Pospíšilová, K. (CZ)
Biedková, P. (CZ)
Vojíková, R. (CZ)
Havlík, J. (CZ)
Bríd O'Leary, V. (CZ)
Černá, M. (CZ)
Bartoš, A. (CZ)
Phillip, T. (CZ)Number of authors 17 Article number 954712 Source Title Frontiers in Neurology. - : Frontiers Media - ISSN 1664-2295
Roč. 13, 1 November 2022 (2022)Number of pages 19 s. Language eng - English Country CH - Switzerland Keywords ischemic stroke ; lncRNA—long non-coding RNA ; motor disability ; rehabilitation ; physiotherapy ; motor recovery ; international classification of functioning ; disability and health model OECD category Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8) Method of publishing Open access Institutional support UIVT-O - RVO:67985807 UT WOS 000885967500001 EID SCOPUS 85142091139 DOI 10.3389/fneur.2022.954712 Annotation INTRODUCTION: While the role of physiotherapy as part of a comprehensive inpatient rehabilitation is indisputable, clear evidence concerning the effectiveness of different rehabilitation managements [interdisciplinary implementing the International Classification of Functioning, disability and health (ICF) vs. multidisciplinary model] and physiotherapy categories (neuroproprioceptive “facilitation, inhibition” vs. motor/skill acquisitions using technologies) are still lacking. In this study, four kinds of comprehensive inpatient rehabilitation with different management and content of physical therapy will be compared. Moreover, focus will be placed on the identification of novel biological molecules reflective of effective rehabilitation. Long non-coding RNAs (lncRNAs) are transcripts (>200 bps) of limited coding potential, which have recently been recognized as key factors in neuronal signaling pathways in ischemic stroke and as such, may provide a valuable readout of patient recovery and neuroprotection during therapeutic progression. METHODS AND ANALYSIS: Adults after the first ischemic stroke in an early sub-acute phase with motor disability will be randomly assigned to one of four groups and undergo a 3 weeks comprehensive inpatient rehabilitation of different types: interdisciplinary team work using ICF model as a guide, multidisciplinary teamwork implementing neuroproprioceptive “facilitation and inhibition” physiotherapy, multidisciplinary teamwork implementing technology-based physiotherapy, and standard multidisciplinary teamwork. Primary (the Goal Attainment Scale, the Patient-Reported Outcomes Measurement Information System, and the World Health Organization Disability Assessment Schedule) and secondary (motor, cognitive, psychological, speech and swallowing functions, functional independence) outcomes will be measured. A blood sample will be obtained upon consent (20 mls, representing pre-rehabilitation molecular) before and after the inpatient program. Primary outcomes will be followed up again 3 and 12 months after the end of the program. The overarching aim of this study is to determine the effectiveness of various rehabilitation managements and physiotherapeutic categories implemented by patients post ischemic stroke via analysis of primary, secondary and long non-coding RNA readouts. This clinical trial will offer an innovative approach not previously tested and will provide new complex analysis along with public assessable molecular biological evidence of various rehabilitation methodology for the alleviation of the effects of ischemic stroke. Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2023 Electronic address https://dx.doi.org/10.3389/fneur.2022.954712
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