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Sensing nitriles with THz spectroscopy of urine vapours from cancers patients subject to chemotherapy
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SYSNO ASEP 0564302 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Sensing nitriles with THz spectroscopy of urine vapours from cancers patients subject to chemotherapy Author(s) Vaks, V. (RU)
Anfertev, V. (RU)
Chernyaeva, M. (RU)
Domracheva, E. (RU)
Yablokov, A. (RU)
Maslennikova, A. (RU)
Zhelesnyak, A. (RU)
Baranov, A. (FR)
Schevchenko, Yuliia (FZU-D)
Pereira, Mauro Fernandes (FZU-D) ORCIDNumber of authors 10 Article number 18117 Source Title Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 12, č. 1 (2022)Number of pages 11 s. Language eng - English Country DE - Germany Keywords superlattice ; THz spectroscopy ; chemotherapy ; detection Subject RIV BM - Solid Matter Physics ; Magnetism OECD category Condensed matter physics (including formerly solid state physics, supercond.) Method of publishing Open access Institutional support FZU-D - RVO:68378271 UT WOS 000876924900100 EID SCOPUS 85140862324 DOI 10.1038/s41598-022-22783-z Annotation A THz nonstationary high-resolution spectrometer based on semiconductor superlattice multipliers is applied to investigate the dynamics of urine composition for cancer patients treated with chemotherapy. The molecular urine composition of healthy volunteers and cancer patients was compared and contrasted. We have found a set of nitriles that either appeared after chemotherapy or increased in content, which are expected as a result of bio-chemical damage to the liver. While no damage can be detected at this stage by existing clinical methods, the identified nitriles are candidates for further large-scale systematic testing towards markers for nephrotoxicity of chemotherapy at an early stage of the treatment, when conventional diagnostics cannot identify substantial organ damage. Comparing the metabolite concentration dynamics with side effects during chemotherapy might then help individuate patients prone to severe complications and correct the treatment. Our devices are game-changers for THz spectroscopy of liquids: they allow spanning four different frequency ranges for a general evaluation of most substances found in the liquid and selecting a spectral interval that bypasses the strong absorption lines from substances such as water and ammonia, which may otherwise mask the detection of the target metabolites. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2023 Electronic address https://hdl.handle.net/11104/0336442
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