Seasonal variation of phenolic compounds in Zostera marina (Zosteraceae) from the Baltic Sea

0561531 - ÚEB 2023 RIV GB eng J - Journal Article
Li, Y. - Rárová, L. - Scarpato, S. - Çiçek, S. S. - Jordheim, M. - Štenclová, T. - Strnad, Miroslav - Mangoni, A. - Zidorn, C.
Seasonal variation of phenolic compounds in Zostera marina (Zosteraceae) from the Baltic Sea.
Phytochemistry. Roč. 196, APR (2022), č. článku 113099. ISSN 0031-9422. E-ISSN 1873-3700
R&D Projects: GA MŠMT(CZ) EF16_019/0000738
Institutional support: RVO:61389030
Keywords : Seasonality of natural product contents * Sulfated phenolics * Zostera marina * Zosteraceae
OECD category: Biochemical research methods
Impact factor: 3.8, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.phytochem.2022.113099

Seasonal variations of phenolic compounds, in leaves of Zostera marina L. from the Baltic Sea near Kiel/Germany were investigated. Dominant compounds were mono- and disulfated flavonoids and phenylpropanoic acids, in particular luteolin 7,3ʹ-O-disulfate and diosmetin 7-O-sulfate as well as rosmarinic acid, a dimeric phenylpropanoid. All detected sulfated flavones showed similar seasonal trends: there were two significant concentration peaks in June and November. Moreover, two geographically distinct flavonoid chemotypes were identified based on their respective main flavonoid, one chemotype was characterized by the prevalence of luteolin 7,3ʹ-O-disulfate (German Baltic Sea), and the other by the prevalence of diosmetin 7-O-sulfate (Norwegian North Sea). Furthermore, an undescribed tetrameric phenylpropanoid, 7ʹʹ,8ʹʹ-didehydrosalvianolic acid B, was isolated and its structure was established by extensive NMR, MS, and CD experiments. This compound inhibited activity of Na+/K+-ATPase in the micro-molar range without any cytotoxic effects against human cancer and normal cells.
Permanent Link: https://hdl.handle.net/11104/0334117