How the surface chemical properties of nanoceria are related to its enzyme-like, antiviral and degradation activity

0560142 - ÚACH 2023 RIV GB eng J - Journal Article
Henych, Jiří - Šťastný, Martin - Ederer, J. - Němečková, Zuzana - Pogorzelska, A. - Tolasz, Jakub - Kormunda, M. - Ryšánek, P. - Bażanów, B. - Stygar, D. - Mazanec, K. - Janoš, P.
How the surface chemical properties of nanoceria are related to its enzyme-like, antiviral and degradation activity.
Environmental Science-Nano. Roč. 9, č. 9 (2022), s. 3485-3501. ISSN 2051-8153. E-ISSN 2051-8161
R&D Projects: GA MŠMT(CZ) LM2018124; GA TA ČR(CZ) TH76030002
Institutional support: RVO:61388980
Keywords : cerium oxide nanoparticles * choline * hydrolysis
OECD category: Inorganic and nuclear chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1039/D2EN00173J

Five different water-based precipitation methods have been used to prepare nanoceria with significantly different redox and acid/base properties, which have been described in detail by a number of analytical methods. Differences in particle size, morphology, porosity, but especially in defect structure and in the surface chemical composition of nanoceria had a crucial impact on their reactivity in several environmentally and biologically oriented model reactions. Ceria-catalyzed hydrolysis of two phosphodiester biomolecules (p-NPPC and p-NP-TMP) revealed high phospholipase C and D mimetic activity of all tested materials. On the other hand, the efficiency in degradation of toxic organophosphates (methyl parathion/oxon, agent VX, GD) is highly dependent on the solvent used (water or acetonitrile). Water slows down the degradation rate, but has a strikingly different effect on each ceria sample, which is related to the ceria surface structure and its interaction with the model compound and/or water. Two materials with a significant number of defects and oxygen-containing surface groups also showed highly virucidal properties against enveloped (adenovirus 5) and non-enveloped (human herpes simplex) viruses while having very low cytotoxicity.
Permanent Link: https://hdl.handle.net/11104/0333928