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Dual role of Fam208a during zygotic cleavage and early embryonic development
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SYSNO ASEP 0554624 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Dual role of Fam208a during zygotic cleavage and early embryonic development Author(s) Grešáková, Veronika (UMG-J)
Novosadová, Vendula (UMG-J)
Procházková, Michaela (UMG-J)
Procházka, Jan (UMG-J) ORCID
Sedláček, Radislav (UMG-J) RIDNumber of authors 5 Article number 112723 Source Title Experimental Cell Research. - : Elsevier - ISSN 0014-4827
Roč. 406, č. 2 (2021)Number of pages 14 s. Publication form Online - E Language eng - English Country US - United States Keywords Genome stability ; Fam208a ; Multipolar spindle apparatus ; hush Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology R&D Projects LM2015040 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED2.1.00/19.0395 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA15-23165S GA ČR - Czech Science Foundation (CSF) Research Infrastructure CCP - 90040 - Ústav molekulární genetiky AV ČR, v. v. i. Method of publishing Limited access Institutional support UMG-J - RVO:68378050 UT WOS 000691380800001 DOI 10.1016/j.yexcr.2021.112723 Annotation Maintenance of genome stability is essential for every living cell as genetic information is repeatedly challenged during DNA replication in each cell division event. Errors, defects, delays, and mistakes that arise during mitosis or meiosis lead to an activation of DNA repair processes and in case of their failure, programmed cell death, i.e. apoptosis, could be initiated. Fam208a is a protein whose importance in heterochromatin maintenance has been described recently. In this work, we describe the crucial role of Fam208a in sustaining genome stability during cellular division. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2022 Electronic address https://www.sciencedirect.com/science/article/abs/pii/S001448272100255X?via%3Dihub
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