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Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics
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SYSNO 0554604 Title Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics Author(s) Gerckens, M. (DE)
Sarnová, Lenka (UMG-J) [91]
Jiroušková, Markéta (UMG-J) [91] RID, ORCID
Gregor, Martin (UMG-J) [91] RID, ORCID
Burgstaller, G. (DE)Corespondence/senior Burgstaller, G. - Korespondující autor Source Title Science Advances. Roč. 7, č. 52 (2021). - : American Association for the Advancement of Science Article number eabb3673 Document Type Článek v odborném periodiku Grant NV17-31538A GA MZd - Ministry of Health (MZ) LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS), CZ - Czech Republic GA18-02699S GA ČR - Czech Science Foundation (CSF) Institutional support UMG-J - RVO:68378050 Language eng Country US Keywords idiopathic pulmonary-fibrosis * growth-factor-beta * selective-inhibition * acute exacerbation * label-free * proteome * matrix * trial * mechanisms * tranilast Cooperating institutions Helmholtz Zentrum Munchen, Inst Lung Biol & Dis ILBD, Munich, Germany
Helmholtz Zentrum Munchen, Comprehens Pneumol Ctr CPC, Munich, Germany
German Ctr Lung Res DZL, Munich, Germany
Helmholtz Zentrum Munchen, Inst Mol Toxicol & Pharmacol, Assay Dev & Screening Platform, German Res Ctr Environm Hlth, Neuherberg, Germany
Strathclyde Univ, Chem & Proc Engn, Glasgow, Lanark, Scotland
Helmholtz Zentrum Munchen, Comprehens Pneumol Ctr Munich DZL CPC M, CPC M BioArch, Munich, Germany
Helmholtz Zentrum Munchen, Inst Med Chem, German Res Ctr Environm Hlth GmbH, Neuherberg, Germany
Leibniz Univ Hannover, Inst Organ Chem, Hannover, Germany
Ctr Biomol Drug Res BMWZ, Hannover, Germany
Asklepios Fachkliniken Munich Gauting, Munich, Germany
Univ Pittsburgh, Dept Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA
Helmholtz Zentrum Munchen, Res Unit Lung Repair & Regenerat, Comprehens Pneumol Ctr CPC, Munich, Germany
Helmholtz Zentrum Munchen, Res Unit Prot Sci, German Res Ctr Environm Hlth GmbH, Neuherberg, Germany
Helmholtz Zentrum Munchen, Inst Expt Genet, D-85764 Neuherberg, Germany
Lund Univ, Wallenberg Ctr Mol Med WCMM, Dept Expt Med Sci, Lund, Sweden
Ludwig Maximillians Univ Munich, Dept Pharm Ctr Drug Res, Pharmaceut Technol & Biopharmaceut, Munich, Germany
German Ctr Diabet Res DZD EV, D-85764 Neuherberg, Germany
Tech Univ Munich, Chair Expt Genet, D-85354 Freising Weihenstephan, Germany
Ludwig Maximillians Univ Munich, Dept Internal Med 5, Munich, Germany
Paracelsus Med Private Univ, Salzburg, Austria
Justus Liebig Univ, Inst Lung Hlth ILH, Giessen, GermanyURL https://www.science.org/doi/10.1126/sciadv.abb3673 Permanent Link http://hdl.handle.net/11104/0329307
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