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Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study
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SYSNO ASEP 0552788 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study Author(s) Nounu, A. (GB)
Richmond, R.C. (GB)
Stewart, I.D. (GB)
Surendran, P. (GB)
Wareham, N.J. (GB)
Butterworth, A. (GB)
Weinstein, S.J. (US)
Albanes, D. (US)
Baron, J.A. (AU)
Hopper, J.L. (KR)
Figueiredo, J.C. (US)
Newcomb, P.A. (US)
Lindor, N.M. (US)
Casey, G. (US)
Platz, E.A. (US)
Marchand, L.L. (US)
Ulrich, C.M. (NL)
Li, Ch.I. (US)
van Dujinhoven, F.J.B. (NL)
Gsur, A. (AT)
Campbell, P.T. (US)
Moreno, V. (ES)
Vodička, Pavel (UEM-P) RID
Vodičková, Ludmila (UEM-P) RID
Amitay, E. (DE)
Alwers, E. (DE)
Chang-Claude, J. (DE)
Sakoda, L.C. (US)
Slattery, M.L. (US)
Schoen, R.E. (US)
Gunter, M.J. (FR)
Castellví-Bel, S. (ES)
Kim, H.R. (KR)
Kweon, S.S. (KR)
Chan, A.T. (US)
Zheng, W. (US)
Bishop, D.T. (GB)
Buchanan, D.D. (AU)
Giles, G.G. (AU)
Gruber, S.B. (US)
Rennert, G. (IL)
Stadler, Z.K. (US)
Harrison, T.A. (NL)
Lin, Y. (NL)
Keku, T.O. (US)
Woods, M.O. (CA)
Schafmayer, C. (DE)
Van Guelpen, B. (SE)
Gallinger, S. (US)
Hampel, H. (US)
Berndt, S.I. (US)
Pharoah, P.D.P. (US)
Lindblom, A. (SE)
Wolk, A. (SE)
Wu, A.H. (US)
White, E. (AT)
Peters, U. (NL)
Drew, D.A. (US)
Scherer, D. (DE)
Bermejo, J.L. (DE)
Brenner, H. (DE)
Hoffmeister, M. (DE)
Williams, A.C. (GB)
Relton, C.L. (GB)Article number 4164 Source Title Nutrients. - : MDPI
Roč. 13, č. 11 (2021)Number of pages 21 s. Language eng - English Country CH - Switzerland Keywords salicylic acid ; aspirin ; colorectal cancer ; Mendelian randomization Subject RIV EB - Genetics ; Molecular Biology OECD category Genetics and heredity (medical genetics to be 3) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000732628500001 EID SCOPUS 85119379732 DOI 10.3390/nu13114164 Annotation Salicylic acid (SA) has observationally been shown to decrease colorectal cancer (CRC) risk. Aspirin (acetylsalicylic acid, that rapidly deacetylates to SA) is an effective primary and secondary chemopreventive agent. Through a Mendelian randomization (MR) approach, we aimed to address whether levels of SA affected CRC risk, stratifying by aspirin use. A two-sample MR analysis was performed using GWAS summary statistics of SA (INTERVAL and EPIC-Norfolk, N = 14,149) and CRC (CCFR, CORECT, GECCO and UK Biobank, 55,168 cases and 65,160 controls). The DACHS study (4410 cases and 3441 controls) was used for replication and stratification of aspirin-use. SNPs proxying SA were selected via three methods: (1) functional SNPs that influence the activity of aspirin-metabolising enzymes, (2) pathway SNPs present in enzymes' coding regions and (3) genome-wide significant SNPs. We found no association between functional SNPs and SA levels. The pathway and genome-wide SNPs showed no association between SA and CRC risk (OR: 1.03, 95% CI: 0.84-1.27 and OR: 1.08, 95% CI: 0.86-1.34, respectively). Results remained unchanged upon aspirin use stratification. We found little evidence to suggest that an SD increase in genetically predicted SA protects against CRC risk in the general population and upon stratification by aspirin use. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2022 Electronic address https://www.mdpi.com/2072-6643/13/11/4164
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