Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients

0551391 - ÚPT 2022 RIV US eng C - Conference Paper (international conference)
Plešinger, Filip - Halámek, Josef - Chládek, J. - Jurák, Pavel - Ivora, Adam - Doležalová, I. - Koriťáková, E. - Jurková, T. - Chrastina, J. - Brázdil, M.
Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients.
43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). New York: IEEE, 2021, s. 5816-5819. ISBN 978-1-7281-1179-7.
[Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) /43./. online (MX), 01.11.2021-05.11.2021]
R&D Projects: GA MZd(CZ) NV19-04-00343
Institutional support: RVO:68081731
Keywords : epilepsy * Vagal Nerve Stimulation * signal processing * heart rate
OECD category: Medical engineering
https://ieeexplore.ieee.org/document/9629577

Vagal Nerve Stimulation (VNS) is used to treat patients with pharmacoresistant epilepsy. However, generally accepted tools to predict VNS response do not exist. Here we examined two heart activity measures - mean RR and pNN50 and their complex behavior during activation in pre-implant measurements. The ECG recordings of 73 patients (38 responders, 36 non-responders) were examined in a 30-sec floating window before (120 sec), during (2x120 sec), and after (120 sec) the hyperventilation by nose and mouth. The VNS response differentiation by pNN50 was significant (min p=0.01) in the hyperventilation by a nose with a noticeable descendant trend in nominal values. The mean RR was significant (p=0.01) in the rest after the hyperventilation by mouth but after an approximately 40-sec delay. Clinical Relevance: Our study shows that pNN50 and mean RR can be used to distinguish between VNS responders and non-responders. However, details of dynamic behavior showed how this ability varies in tested measurement segments.
Permanent Link: http://hdl.handle.net/11104/0326805