Quantum dot luminescent probe for Caspase 3/7 imaging inside cells

0549389 - ÚIACH 2022 RIV CZ eng C - Conference Paper (international conference)
Procházková, Markéta - Klepárník, Karel
Quantum dot luminescent probe for Caspase 3/7 imaging inside cells.
Proceedings of the 17th International Students Conference “Modern Analytical Chemistry”. Praha: Přírodovědecká fakulta Univerzity Karlovy, 2021 - (Nesměrák, K.), s. 158-163. ISBN 978-80-7444-089-2.
[International Students Conference 'Modern Analytical Chemistry' /17./. Praha (CZ), 16.09.2021-17.09.2021]
R&D Projects: GA ČR(CZ) GA20-00726S
Institutional support: RVO:68081715
Keywords : caspase * fluorescence * quantum dot
OECD category: Analytical chemistry

Two step synthesis of luminescent probe based on ligand-exchange in the first step and the specific reaction of amino group in the second step was optimized. The luminescence properties of the final product were checked by time course of
active recombinant caspase protein reaction under the model conditions in fluorimeter. The novel luminescent probe enables long-time imaging of active caspases in living cells or tissues.
Permanent Link: http://hdl.handle.net/11104/0325409