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Interleukin 4 inducible 1 gene (IL4I1) is induced in chicken phagocytes by Salmonella Enteritidis infection
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SYSNO ASEP 0539895 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Interleukin 4 inducible 1 gene (IL4I1) is induced in chicken phagocytes by Salmonella Enteritidis infection Author(s) Elsheimer-Matulova, M. (CZ)
Polanský, O. (CZ)
Seidlerova, Z. (CZ)
Varmužová, K. (CZ)
Štěpánová, H. (CZ)
Fedr, Radek (BFU-R) ORCID
Rychlík, I. (CZ)Number of authors 7 Article number 67 Source Title Veterinary Research. - : BioMed Central - ISSN 0928-4249
Roč. 51, č. 1 (2020)Number of pages 8 s. Publication form Online - E Language eng - English Country FR - France Keywords amino-acid oxidase ; hydrogen-peroxide ; dendritic cells ; immune-response ; expression ; typhimurium Subject RIV GJ - Animal Vermins ; Diseases, Veterinary Medicine OECD category Veterinary science Method of publishing Open access Institutional support BFU-R - RVO:68081707 UT WOS 000536286400003 EID SCOPUS 85084625324 DOI 10.1186/s13567-020-00792-y Annotation In attempt to identify genes that are induced in chickens by Salmonella Enteritidis we identified a new highly inducible gene, interleukin 4 induced 1 gene (IL4I1). IL4I1 reached its peak expression (458x induction) in the cecum of newly hatched chickens 4 days post-infection and remained upregulated for an additional 10 days. IL4I1 was expressed and induced in macrophages and granulocytes, both at the mRNA and protein level. IL4I1 was expressed and induced also in CD4 and gamma delta T-lymphocytes though at a 50-fold lower level than in phagocytes. Expression of IL4I1 was not detected in CD8 T lymphocytes or B lymphocytes. Mutation of IL4I1 in chicken HD11 macrophages did not affect their bactericidal capacity against S. Enteritidis but negatively affected their oxidative burst after PMA stimulation. We therefore propose that IL4I1 is not directly involved in bactericidal activity of phagocytes and, instead, it is likely involved in the control of inflammatory response and signaling to T and B lymphocytes. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2021 Electronic address https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-020-00792-y
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