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Intravenously administered d-mannitol-coated maghemite nanoparticles cause elemental anomalies in selected rat organs
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SYSNO ASEP 0535544 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Intravenously administered d-mannitol-coated maghemite nanoparticles cause elemental anomalies in selected rat organs Author(s) Matusiak, K. (PL)
Drózdz, A. (PL)
Setkowicz, Z. (PL)
Kubala-Kukus, A. (PL)
Stabrawa, I. (PL)
Ciarach, M. (PL)
Janeczko, K. (PL)
Horák, Daniel (UMCH-V) RID, ORCID
Babič, Michal (UMCH-V) RID, ORCID
Chwiej, J. (PL)Source Title Metallomics. - : Oxford University Press - ISSN 1756-5901
Roč. 12, č. 11 (2020), s. 1811-1821Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords magnetic nanoparticles ; biomedical applications ; drug products Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000590393400014 EID SCOPUS 85096457070 DOI 10.1039/D0MT00158A Annotation In this study novel D-mannitol coated maghemite nanoparticles (MIONPs) are presented in terms of their influence on elemental homeostasis of living organisms and for this purpose highly sensitive total reflection X-ray fluorescence was used. Because of the biological indifference of D-mannitol and presumed lower toxicity of maghemite, compared to the most commonly used magnetite in nanomedicine, such nanoparticles seem to be promising candidates for biomedical applications. The examined dose of MIONPs was comparable with one of the lowest doses used in medical diagnostics. However, it should be emphasized that the amount of iron injected in this form is still significant compared to its total content in organs, especially in kidneys or the heart, and may easily disrupt their elemental homeostasis. The aim of the present study was to evaluate the elemental changes occurring in selected rat organs after injecting a low dose of MIONPs. The results were compared with those obtained for previously examined PEG-coated nanoparticles with magnetite cores. In the light of our findings the elemental changes observed after exposure to MIONPs were less extensive than those following PEG-coated magnetite nanoparticle administration. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2021 Electronic address https://pubs.rsc.org/en/content/articlelanding/2020/MT/D0MT00158A#!divAbstract
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