Na+/K+-ATPase and lipid peroxidation in forebrain cortex and hippocampus of sleep-deprived rats treated with therapeutic lithium concentration for different periods of time

Vošahlíková, Miroslava; Roubalová, Lenka; Cechová, Kristína; Kaufman, Jonáš; Musil, Stanislav; Mikšík, Ivan; Alda, M.; Svoboda, Petr

doi:https://dx.doi.org/10.1016/j.pnpbp.2020.109953

Number of the records: 1

Na+/K+-ATPase and lipid peroxidation in forebrain cortex and hippocampus of sleep-deprived rats treated with therapeutic lithium concentration for different periods of time

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SYSNO ASEP	0531295
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Na+/K+-ATPase and lipid peroxidation in forebrain cortex and hippocampus of sleep-deprived rats treated with therapeutic lithium concentration for different periods of time
Author(s)	Vošahlíková, Miroslava (FGU-C)_{RID, ORCID, SAI} Roubalová, Lenka (FGU-C)_{RID, ORCID, SAI} Cechová, Kristína (FGU-C)_{RID, ORCID} Kaufman, Jonáš (FGU-C) Musil, Stanislav (UIACH-O)_{RID, ORCID} Mikšík, Ivan (FGU-C)_{RID, ORCID, SAI} Alda, M. (CZ) Svoboda, Petr (FGU-C)_{RID, ORCID}
Article number	109953
Source Title	Progress in Neuro-Psychopharmacology & Biological Psychiatry. - : Elsevier - ISSN 0278-5846 Roč. 102, Aug 30 (2020)
Number of pages	16 s.
Language	eng - English
Country	US - United States
Keywords	lithium ; sleep deprivation ; Na+/K+-ATPase ; lipid peroxidation ; rat brain
Subject RIV	ED - Physiology
OECD category	Physiology (including cytology)
Subject RIV - cooperation	Institute of Analytical Chemistry - Analytical Chemistry, Separation
R&D Projects	GA17-07070S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	FGU-C - RVO:67985823 ; UIACH-O - RVO:68081715
UT WOS	000548248400011
EID SCOPUS	85084368234
DOI	10.1016/j.pnpbp.2020.109953
Annotation	Lithium (Li) is a typical mood stabilizer and the first choice for treatment of bipolar disorder (BD). Despite an extensive clinical use of Li, its mechanisms of action remain widely different and debated. In this work, we studied the time-course of the therapeutic Li effects on ouabain-sensitive Na+/K+-ATPase in forebrain cortex and hippocampus of rats exposed to 3-day sleep deprivation (SD). We also monitored lipid peroxidation as malondialdehyde (MDA) production. In samples of plasma collected from all experimental groups of animals, Li concentrations were followed by ICP-MS. The acute (1 day), short-term (7 days) and chronic (28 days) treatment of rats with Li resulted in large decrease of Na+/K+-ATPase activity in both brain parts. At the same time, SD of control, Li-untreated rats increased Na+/K+-ATPase along with increased production of MDA. The SD-induced increase of Na+/K+-ATPase and MDA was attenuated in Li-treated rats. While SD results in a positive change of Na+/K+-ATPase, the inhibitory effect of Li treatment may be interpreted as a pharmacological mechanism causing a normalization of the stress-induced shift and return the Na+/K+-ATPase back to control level. We conclude that SD alone up-regulates Na+/K+-ATPase together with increased peroxidative damage of lipids. Chronic treatment of rats with Li before SD, protects the brain tissue against this type of damage and decreases Na+/K+-ATPase level back to control level.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2021
Electronic address	https://doi.org/10.1016/j.pnpbp.2020.109953

Number of the records: 1