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Glycogen as an advantageous polymer carrier in cancer theranostics: straightforward in vivo evidence
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SYSNO ASEP 0525299 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Glycogen as an advantageous polymer carrier in cancer theranostics: straightforward in vivo evidence Author(s) Gálisová, A. (CZ)
Jirátová, M. (CZ)
Rabyk, Mariia (UMCH-V) RID, ORCID
Sticová, E. (CZ)
Hájek, M. (CZ)
Hrubý, Martin (UMCH-V) RID, ORCID
Jirák, D. (CZ)Article number 10411 Source Title Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 10, č. 1 (2020), s. 1-11Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords glycogen ; polymers ; drug delivery system Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects LTC19032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA18-07983S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000545967200008 EID SCOPUS 85086831274 DOI 10.1038/s41598-020-67277-y Annotation As a natural polysaccharide polymer, glycogen possesses suitable properties for use as a nanoparticle carrier in cancer theranostics. Not only it is inherently biocompatible, it can also be easily chemically modified with various moieties. Synthetic glycogen conjugates can passively accumulate in tumours due to enhanced permeability of tumour vessels and limited lymphatic drainage (the EPR effect). For this study, we developed and examined a glycogen-based carrier containing a gadolinium chelate and near-infrared fluorescent dye. Our aim was to monitor biodistribution and accumulation in tumour-bearing rats using magnetic resonance and fluorescence imaging. Our data clearly show that these conjugates possess suitable imaging and tumour-targeting properties, and are safe under both in vitro and in vivo conditions. Additional modification of glycogen polymers with poly(2-alkyl-2-oxazolines) led to a reduction in the elimination rate and lower uptake in internal organs (lower whole-body background: 45% and 27% lower MRI signals of oxazoline-based conjugates in the liver and kidneys, respectively compared to the unmodified version). Our results highlight the potential of multimodal glycogen-based nanopolymers as a carrier for drug delivery systems in tumour diagnosis and treatment. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2021 Electronic address https://www.nature.com/articles/s41598-020-67277-y
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