Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides

Hubáček, J. A.; Pelclová, D.; Dlouhá, D.; Mikuška, Pavel; Dvořáčková, Š.; Vlčková, Š.; Fenclová, Z.; Ondráček, J.; Koštejn, Martin; Schwarz, Jaroslav; Popov, A.; Křůmal, Kamil; Lánská, V.; Coufalík, Pavel; Zakharov, S.; Ždímal, Vladimír

doi:https://dx.doi.org/10.2486/indhealth.2018-0146

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Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides

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SYSNO ASEP	0517643
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides
Author(s)	Hubáček, J. A. (CZ) Pelclová, D. (CZ) Dlouhá, D. (CZ) Mikuška, Pavel (UIACH-O)_{RID, ORCID} Dvořáčková, Š. (CZ) Vlčková, Š. (CZ) Fenclová, Z. (CZ) Ondráček, J. (CZ) Koštejn, Martin (UCHP-M)_{RID, SAI, ORCID} Schwarz, Jaroslav (UCHP-M)_{RID, ORCID, SAI} Popov, A. (CZ) Křůmal, Kamil (UIACH-O)_{RID, ORCID} Lánská, V. (CZ) Coufalík, Pavel (UIACH-O)_{ORCID, RID} Zakharov, S. (CZ) Ždímal, Vladimír (UCHP-M)_{RID, ORCID, SAI}
Number of authors	16
Source Title	Industrial Health. - : National Institute of Occupational Safety and Health - ISSN 0019-8366 Roč. 57, č. 6 (2019), s. 741-744
Number of pages	4 s.
Publication form	Print - P
Language	eng - English
Country	JP - Japan
Keywords	telomere lenght ; follow-up ; metal nanoparticles
Subject RIV	CB - Analytical Chemistry, Separation
OECD category	Analytical chemistry
Subject RIV - cooperation	Institute of Chemical Process Fundamentals - Solid Waste and Recycling
R&D Projects	GBP503/12/G147 GA ČR - Czech Science Foundation (CSF)
	GA18-02079S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Open access
Institutional support	UIACH-O - RVO:68081715 ; UCHP-M - RVO:67985858
UT WOS	000502030800010
EID SCOPUS	85075749071
DOI	10.2486/indhealth.2018-0146
Annotation	The aim of this study was to ascertain whether long-term occupational exposure to nanoparticles would affect relative leukocyte telomere length (LrTL). We analysed occupational exposure to size-resolved aerosol particles, with special emphasis on nanoparticles at two workshops: i/ the production of nanocomposites containing metal oxides, ii/ laboratory to test experimental exposure of nano-CuO to rodents. Thirty five exposed researchers (age 39.5 ± 12.6 yr, exposure duration 6.0 ± 3.7 yr) and 43 controls (40.4 ± 10.5 yr) were examined. LrTL did not significantly (p=0.14) differ between the exposed researchers (0.92 ± 0.13) and controls (0.86 ± 0.15). In addition, no significant correlation (r=−0.22, p=0.22) was detected between the duration of occupational exposure and LrTL. The results remained non-significant after multiple adjustments for age, sex and smoking status. Our pilot results suggest that relative leukocyte telomere length is not affected by occupational exposure to nanoparticles.
Workplace	Institute of Analytical Chemistry
Contact	Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234
Year of Publishing	2020
Electronic address	https://www.jstage.jst.go.jp/article/indhealth/57/6/57_2018-0146/_pdf

Number of the records: 1