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Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome
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SYSNO ASEP 0517196 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Crystalline Wax Esters Regulate the Evaporation Resistance of Tear Film Lipid Layers Associated with Dry Eye Syndrome Author(s) Paananen, Riku O. (UFCH-W)
Javanainen, Matti (UOCHB-X) RID, ORCID
Holopainen, J. M. (FI)
Vattulainen, I. (FI)Source Title Journal of Physical Chemistry Letters. - : American Chemical Society - ISSN 1948-7185
Roč. 10, č. 14 (2019), s. 3893-3898Number of pages 6 s. Language eng - English Country US - United States Keywords force-field ; permeation ; water ; temperature ; meibum ; oxygen Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry Subject RIV - cooperation Institute of Organic Chemistry and Biochemistry - Physical ; Theoretical Chemistry Method of publishing Open access Institutional support UFCH-W - RVO:61388955 ; UOCHB-X - RVO:61388963 UT WOS 000476694300011 EID SCOPUS 85069849171 DOI 10.1021/acs.jpclett.9b01187 Annotation Dry eye syndrome (DES), one of the most common ophthalmological diseases, is typically caused by excessive evaporation of tear fluid from the ocular surface. Excessive evaporation is linked to impaired function of the tear film lipid layer (TFLL) that covers the aqueous tear film. The principles of the evaporation resistance of the TFLL have remained unknown, however. We combined atomistic simulations with Brewster angle microscopy and surface potential experiments to explore the organization and evaporation resistance of films composed of wax esters, one of the main components of the TFLL. The results provide evidence that the evaporation resistance of the TFLL is based on crystalline-state layers of wax esters and that the evaporation rate is determined by defects in the TFLL and its coverage on the ocular surface. On the basis of the results, uncovering the nonequilibrium spreading and crystallization of TFLL films has potential to reveal new means of treating DES. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2020 Electronic address http://hdl.handle.net/11104/0302485
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