Number of the records: 1  

Advances in Chemical Biology

  1. 1.
    SYSNO ASEP0502870
    Document TypeM - Monograph Chapter
    R&D Document TypeMonograph Chapter
    TitleFAM208A: a new target in the search for antiretroviral drugs
    Author(s) Epp, Trevor (UMG-J) RID
    Schuster, Bjorn (UMG-J)
    Chawengsaksophak, Kallayanee (UMG-J) ORCID
    Source TitleAdvances in Chemical Biology. - Praha : OPTIO CZ, 2019 / Bartůněk Petr - ISBN 978-80-88011-03-3
    Pagess. 40-49
    Number of pages9 s.
    Number of copy50
    Number of pages210
    Publication formPrint - P
    Languageeng - English
    CountryCZ - Czech Republic
    KeywordsLINE-1 retrotransposon, , ; FAM208A ; human silencing hub
    Subject RIVEB - Genetics ; Molecular Biology
    OECD categoryCell biology
    R&D ProjectsLO1220 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Institutional supportUMG-J - RVO:68378050
    AnnotationA previously unknown gene, FAM208A, has now featured predominantly in several different genome-wide screens for modifiers of gene silencing. It is now known that FAM208A exists within a core epigenetic silencing complex comprising also MPHOSPH8 and PPHLN1. This complex, termed HUSH (human silencing hub), binds pre-existing, repressive H3K9me3 marks and then catalyses the local spread of these same marks through the recruitment of the H3K9-methyltransferase, SETDB1. Here we discuss the role of forward genetic screens in the discovery of FAM208A functions and the prospects of employing forward chemical genetics screens to further probe its mechanism of action.
    WorkplaceInstitute of Molecular Genetics
    ContactNikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
    Year of Publishing2019
Number of the records: 1  

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