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Possible Pathogenetic Mechanisms and New Therapeutic Approaches of Pes Equinovarus
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SYSNO ASEP 0477251 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Possible Pathogenetic Mechanisms and New Therapeutic Approaches of Pes Equinovarus Author(s) Ošťádal, M. (CZ)
Lišková, Jana (FGU-C) RID, ORCID
Hadraba, Daniel (FGU-C) RID, ORCID, SAI
Eckhardt, Adam (FGU-C) RID, ORCIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 66, č. 3 (2017), s. 403-410Number of pages 8 s. Language eng - English Country CZ - Czech Republic Keywords Pes equinovarus ; clubfoot ; pathogenetic mechanisms ; fibrosis Subject RIV FI - Traumatology, Orthopedics OECD category Orthopaedics R&D Projects NV15-29153A GA MZd - Ministry of Health (MZ) Institutional support FGU-C - RVO:67985823 UT WOS 000405692500004 EID SCOPUS 85026385900 DOI 10.33549/physiolres.933404 Annotation Idiopathic pes equinovarus (clubfoot) is a congenital deformity of the foot and lower leg defined as a fixation of the foot in plantar flexion, adduction, supination and varus. The deformity does not affect only the foot position, which is usually investigated by radiography, CT, micro-CT, MRI or ultrasound but logically influence the whole gait biomechanics. It is supposed, that clubfoot belongs to a group of fibroproliferative disorders whose origin and multi-hierarchical effect remain unknown. It has been suggested that fibroblasts and growth factors may be involved. To gain a more global view, direct analysis of the protein composition of extracellular matrix, a proteomic approach was used. At present two principle methods are mostly used for the treatment of clubfoot: physiotherapy and the Ponseti method. The determination of the general biological and biomechanical parameters for various regions of the clubfoot can potentially help in the understanding of the mechanisms participating on this serious anomaly and thus contribute to the development of the more efficient therapeutic approach. This review summarizes the present knowledge on the possible pathogenetic mechanisms participating in the development of the clubfoot and their possible relation to the new therapeutic approaches. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
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