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Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes
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SYSNO ASEP 0474712 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes Author(s) Javanainen, M. (FI)
Melcrová, Adéla (UFCH-W)
Magarkar, Aniket (UOCHB-X)
Jurkiewicz, Piotr (UFCH-W) RID, ORCID
Hof, Martin (UFCH-W) RID, ORCID
Jungwirth, Pavel (UOCHB-X) RID, ORCID
Martinez-Seara, Hector (UOCHB-X) RID, ORCIDSource Title Chemical Communications. - : Royal Society of Chemistry - ISSN 1359-7345
Roč. 53, č. 39 (2017), s. 5380-5383Number of pages 4 s. Language eng - English Country GB - United Kingdom Keywords phospholipid bilayers ; molecular dynamics ; fluorescence Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry Subject RIV - cooperation Institute of Organic Chemistry and Biochemistry - Physical ; Theoretical Chemistry R&D Projects GA17-03160S GA ČR - Czech Science Foundation (CSF) GA16-01074S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UFCH-W - RVO:61388955 ; UOCHB-X - RVO:61388963 UT WOS 000401118400005 EID SCOPUS 85021689400 DOI 10.1039/c7cc02208e Annotation Adsorption of metal cations onto a cellular membrane changes its properties, such as interactions with charged moieties or the propensity for membrane fusion. It is, however, unclear whether cells can regulate ion adsorption and the related functions via locally adjusting their membrane composition. We employed fluorescence techniques and computer simulations to determine how the presence of cholesterol—a key molecule inducing membrane heterogeneity—affects the adsorption of sodium and calcium onto zwitterionic phosphatidylcholine bilayers. We found that the transient adsorption of sodium is dependent on the number of phosphatidylcholine head groups, while the strong surface binding of calcium is determined by the available surface area of the membrane. Cholesterol thus does not affect sodium adsorption and only plays an indirect role in modulating the adsorption of calcium by increasing the total surface area of the membrane. These observations also indicate how lateral lipid heterogeneity can regulate various ion-induced processes including adsorption of peripheral proteins, nanoparticles, and other molecules onto membranes.
Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2018
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