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Mechanisms of hormonal regulation of the peripheral circadian clock in the colon
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SYSNO ASEP 0473974 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mechanisms of hormonal regulation of the peripheral circadian clock in the colon Author(s) Polidarová, Lenka (FGU-C) RID, ORCID
Houdek, Pavel (FGU-C) ORCID
Sládek, Martin (FGU-C) RID, ORCID, SAI
Novosadová, Zuzana (FGU-C) ORCID
Pácha, Jiří (FGU-C) RID, ORCID
Sumová, Alena (FGU-C) RID, ORCIDSource Title Chronobiology International - ISSN 0742-0528
Roč. 34, č. 1 (2017), s. 1-16Number of pages 16 s. Language eng - English Country US - United States Keywords circadian clock ; colon ; entrainment Subject RIV ED - Physiology OECD category Physiology (including cytology) R&D Projects GA14-07711S GA ČR - Czech Science Foundation (CSF) GA13-08304S GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000396728000001 EID SCOPUS 84988640233 DOI 10.1080/07420528.2016.1231198 Annotation Colonic function is controlled by an endogenous clock that allows the colon to optimize its function on the daytime basis. For the first time, this study provided evidence that the clock is synchronized by rhythmic hormonal signals. In rat colon, adrenalectomy decreased and repeated applications of dexamethasone selectively rescued circadian rhythm in the expression of the clock gene Per1. Dexamethasone entrained the colonic clock in explants from mPer2Luc mice in vitro. In contrast, pinealectomy had no effect on the rat colonic clock, and repeated melatonin injections were not able to rescue the clock in animals maintained in constant light. Additionally, melatonin did not entrain the clock in colonic explants from mPer2Luc mice in vitro. However, melatonin affected rhythmic regulation of Nr1d1 gene expression in vivo. The findings provide novel insight into possible beneficial effects of glucocorticoids in the treatment of digestive tract-related diseases, greatly exceeding their anti-inflammatory action. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
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