Impact of Air Pollution to Genome of Newborns.

0472879 - ÚEM 2017 RIV CZ eng J - Journal Article
Šrám, Radim - Rössner ml., Pavel - Rössnerová, Andrea - Dostál, Miroslav - Milcová, Alena - Švecová, Vlasta - Pulkrabová, J. - Hajšlová, J. - Velemínský Jr., M.
Impact of Air Pollution to Genome of Newborns.
Central European Journal of Public Health. Roč. 24, dec (2016), S40-S44. ISSN 1210-7778. E-ISSN 1803-1048
R&D Projects: GA ČR(CZ) GA13-13458S
Institutional support: RVO:68378041
Keywords : air pollution * diet * genetic damage * molecular epidemiology
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 0.682, year: 2016

The Northern Moravia Region is the most polluted region in the Czech Republic by particulate matter (PM2.5) and carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) as benzo[a]pyrene (B[a]P) by heavy industry and local heating. This specific situation was used to study the impact of air pollution on newborns in the exposed Karviná district and control district of České Budějovice. Biological material from newborns and mothers was collected in summer and winter seasons. This project is highly detailed, analyzing the concentrations of PAHs in ambient air and diet, in human breast milk, in the urine of mothers and newborns, using biomarkers of genetic damage as DNA adducts and gene expression analysis, biomarkers of oxidative stress as 8-oxodG adducts and lipid peroxidation (15-F2t-isoprostane immunoassay). All 400 children, for whom the biomarker data at delivery were obtained, will be followed for morbidity up to 2 years of age. The Northern Moravia Region seems to be to be a model area for studying the long-term impact of human health exposure to c-PAHs. Our observations will indicate possible genetic and oxidative damage in newborns, which may significantly affect their morbidity.
Permanent Link: http://hdl.handle.net/11104/0270096