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The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria
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SYSNO ASEP 0465807 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria Author(s) Rohlenová, Kateřina (BTO-N) ORCID, RID
Neužil, Jiří (BTO-N) RID
Rohlena, Jakub (BTO-N) RID, ORCIDNumber of authors 3 Source Title Biological Chemistry. - : Walter de Gruyter - ISSN 1431-6730
Roč. 397, č. 7 (2016), s. 607-615Number of pages 9 s. Language eng - English Country DE - Germany Keywords alpha-tocopheryl succinate ; mitochondria ; oxidase subunit-ii ; protein-kinase b Subject RIV EB - Genetics ; Molecular Biology R&D Projects ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support BTO-N - RVO:86652036 UT WOS 000377892600004 DOI 10.1515/hsz-2016-0130 Annotation Altered metabolism and resistance to cell death are typical hallmarks of cancer phenotype. Mitochondria are organelles central to cellular metabolism as well as to cell death induction. Hyperactivation of pro-survival and pro-proliferative pathways such as PI3K/AKT leads to cancer initiation, which affects mitochondria. Growing body of evidence indicates that oncogenes such as HER2, EGFR and RAS, as well as the downstream members of the PI3K/AKT signaling pathway, directly regulate mitochondria by translocating to the organelle. Here we discuss evidence of this scenario and consider mechanisms for direct regulation of mitochondrial function. Being in close proximity to mitochondrial bioenergetics machinery as well as to the regulators/executors of programed cell death, oncogenes in mitochondria may be ideally placed to perform this task. This represents a thus far under-explored area, which may be relevant to better understanding of cancer initiation, progression and treatment. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2017
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