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CD46 and β1 integrin dynamics during sperm acrosome reaction
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SYSNO ASEP 0463158 Document Type C - Proceedings Paper (int. conf.) R&D Document Type The record was not marked in the RIV Title CD46 and β1 integrin dynamics during sperm acrosome reaction Author(s) Dvořáková-Hortová, Kateřina (BTO-N)
Frolíková, Michaela (BTO-N) ORCID
Děd, Lukáš (BTO-N) RID
Šebková, Nataša (BTO-N)Number of authors 4 Source Title Indian Journal of Psychiatry - ISSN 0019-5545 Number of pages 1 s. Action 19th European tetsis Workshop - Eurpoean Workshop on the molecular and cellular endocrinology of the testis Event date 11.06.2016-15.06.2016 VEvent location Saint-Malo Country FR - France Event type EUR Language eng - English Country FR - France Keywords CD46 ; β1-integrin ; sperm capacitation ; acrosome reaction ; STED Subject RIV EC - Immunology R&D Projects GA14-05547S GA ČR - Czech Science Foundation (CSF) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support BTO-N - RVO:86652036 Annotation CD46 půays an important role during fertilization. It is localized in the acrosome membrane and its role is associated with acrosomal stability. CD46 is probably involved in signaling pathways triggering AR.Failure of CD46 expression is suspected to alter intracellular signaling and disrupt the acrosome region due to affecting a distribution of integrins and lately actin. It also associates, through membrane integrins, with specific MAP kinases involved in the AR. Integrins interact with many cytoskeletal proteins, therefore changes in the actin cytoskeleton before and after AR may lead to changes in the association and localization of CD46 and β1-integrin. The interaction of these proteins in sper can be predicted, however it still has not been shown. It was documented that essential sperm-egg fusion protein IZUMO1 changes their localization during the AR towards the place where sperm-egg fusion happens. This process is made possible by enzyme Tssk6 which activity affects actin cytoskeleton and itsrole in the transport of sperm proteins into the postacrosome region of the sperm head. The question remains, whether CD46 and β1-integrin changes its localization during the acrosome reaction and whether this possible change is affected by the actin cytoskeleton. Faulty restructuring of these proteins throughout the capacitation may therefore, results in unsuccessful fusion of acrosomal membrane at the beggining of the AR. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2017
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