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Chiral analysis and characterization of acyclic nucleoside phosphonates-based antiviral drugs by capillary electrophoresis
- 1.0398075 - ÚOCHB 2014 SK eng C - Conference Paper (international conference)
Kašička, Václav - Šolínová, Veronika - Sázelová, Petra - Mikysková, Hana - Koval, Dušan - Břehová, Petra - Krečmerová, Marcela - Janeba, Zlatko - Holý, Antonín
Chiral analysis and characterization of acyclic nucleoside phosphonates-based antiviral drugs by capillary electrophoresis.
Analytické metódy a zdravie človeka. 19. medzinárodná konferencia. Bratislava: Slovenská vákuová spoločnosť, 2013 - (Bodor, R.; Okenicová, L.; Staňová, A.), s. 14-17. ISBN 978-80-971179-1-7.
[Analytické metódy a zdravie človeka. Medzinárodná konferencia /19./. Rajecké Teplice (SK), 24.06.2013-27.06.2013]
R&D Projects: GA ČR(CZ) GAP206/12/0453; GA ČR GA13-17224S; GA MŠMT(CZ) ME10040; GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * chiral analysis * capillary electrophoresis
Subject RIV: CB - Analytical Chemistry, Separation
New capillary electrophoresis (CE) methods were developed for chiral analysis and characterization of acyclic nucleoside phosphonates (ANPs)-based antivirotics and related compounds. Chiral analysis of an important anti-AIDS drug, 9-(R)-[2-(phosphonomethoxy)-propyl]adenine ((R)-PMPA, tenofovir) and related ANPs was accomplished by CE in alkaline background electrolytes (BGEs) using beta-cyclodextrin as chiral selector. Using the UV-absorption detection at 206 nm, the detection limits of the analyzed ANPs were in the submicromolar to low micromolar range.
Permanent Link: http://hdl.handle.net/11104/0225700
Number of the records: 1