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Biophysical insights into cancer transformation and treatment
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SYSNO ASEP 0396879 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biophysical insights into cancer transformation and treatment Author(s) Pokorný, Jiří (URE-Y) RID
Foletti, A. (CH)
Kobilková, J. (CZ)
Jandová, Anna (URE-Y)
Vrba, J. (CZ)
Vrba, J. jr. (CZ)
Nedbalová, M. (CZ)
Čoček, A. (CZ)
Danani, A. (CH)
Tuszynski, J. A. (CA)Number of authors 10 Source Title Scientific World Journal - ISSN 1537-744X
Roč. 2013, č. 195028 (2013)Number of pages 11 s. Publication form Online - E Language eng - English Country US - United States Keywords fatty acid ; mitochondrial membrane ; cancer cell Subject RIV JA - Electronics ; Optoelectronics, Electrical Engineering R&D Projects GAP102/11/0649 GA ČR - Czech Science Foundation (CSF) Institutional support URE-Y - RVO:67985882 UT WOS 000320786100001 EID SCOPUS 84880162565 DOI 10.1155/2013/195028 Annotation Biological systems are hierarchically self-organized complex structures characterized by nonlinear interactions. Biochemical energy is transformed into work of physical forces required for various biological functions. We postulate that energy transduction depends on endogenous electrodynamic fields generated by microtubules. Microtubules and mitochondria colocalize in cells with microtubules providing tracks for mitochondrial movement. Besides energy transformation, mitochondria form a spatially distributed proton charge layer and a resultant strong static electric field, which causes water ordering in the surrounding cytosol. These effects create conditions for generation of coherent electrodynamic field. The metabolic energy transduction pathways are strongly affected in cancers. Mitochondrial dysfunction in cancer cells (Warburg effect) or in fibroblasts associated with cancer cells (reverse Warburg effect) results in decreased or increased power of the generated electromagnetic field, respectively, and shifted and rebuilt frequency spectra. Disturbed electrodynamic interaction forces between cancer and healthy cells may favor local invasion and metastasis. A therapeutic strategy of targeting dysfunctional mitochondria for restoration of their physiological functions makes it possible to switch on the natural apoptotic pathway blocked in cancer transformed cells. Experience with dichloroacetate in cancer treatment and reestablishment of the healthy state may help in the development of novel effective drugs aimed at the mitochondrial function Workplace Institute of Radio Engineering and Electronics Contact Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Year of Publishing 2014
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