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Polymer coatings for delivery of nucleic acid therapeutics
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SYSNO ASEP 0378755 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polymer coatings for delivery of nucleic acid therapeutics Author(s) Laga, Richard (UMCH-V) RID, ORCID
Carlisle, R. (GB)
Tangney, M. (IE)
Ulbrich, Karel (UMCH-V) RID
Seymour, L. W. (GB)Source Title Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 161, č. 2 (2012), s. 537-553Number of pages 17 s. Language eng - English Country NL - Netherlands Keywords gene delivery ; polymer coating ; viral vectors Subject RIV CD - Macromolecular Chemistry R&D Projects IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000305790300037 DOI 10.1016/j.jconrel.2012.02.013 Annotation Gene delivery remains the greatest challenge for treatment of a broad range of diseases. Combining stability during the delivery phase with activation and transgene expression following arrival at the target site requires sophisticated vectors. Efficient intravenous delivery is the greatest hurdle, with synthetic vectors frequently found to be unstable in the bloodstream, and viral vectors often recognized by both the innate and the adaptive immune system. Both types of vectors benefit from coating with hydrophilic polymers. Self-assembling polyelectrolyte non-viral vectors can achieve both steric and lateral stabilization, endowing them with much improved systemic circulation properties and better access to disseminated targets; similarly viral vectors can be ‘stealthed’ and their physical properties modulated. Both types of vectors may also have their tropism changed following chemical linkage of novel ligands to the polymer coating enabling them site- or cell-specific delivery. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2013
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