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A selected ion flow tube mass spectrometry study of ammonia in mouth- and nose-exhaled breath and in the oral cavity
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SYSNO ASEP 0315002 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A selected ion flow tube mass spectrometry study of ammonia in mouth- and nose-exhaled breath and in the oral cavity Title Analýza amoniaku v dechu exhalovaném ústy a nosem a vzduchu v dutině ústní pomocí hmotnostní spektrometrie v proudové trubici s vybranými ionty (SIFT-MS) Author(s) Smith, D. (GB)
Wang, T. (GB)
Pysanenko, A. (GB)
Španěl, Patrik (UFCH-W) RID, ORCIDSource Title Rapid Communications in Mass Spectrometry. - : Wiley - ISSN 0951-4198
Roč. 22, č. 6 (2008), s. 783-789Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords SIFT-MS ; oral cavity Subject RIV CF - Physical ; Theoretical Chemistry CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000254593700005 DOI 10.1002/rcm.3434 Annotation A study has been carried out, involving three healthy volunteers, of the ammonia levels in breath exhaled via the mouth and via the nose and in the static oral cavity using on-line, selected ion flow tube mass spectrometry (SIFT-MS), obviating the problems associated with sample collection of ammonia. The unequivocal conclusion drawn is that the ammonia appearing in the mouth-exhaled breath of the three volunteers is largely generated in the oral cavity and that the ammonia originating at the alveolar interface in the lungs is typically at levels less than about 100 parts-per-billion, which is a small fraction of the total breath ammonia. This leads to the recommendation that exhaled breath analyses should focus on nose-exhaled breath if the objective is to use breath analysis to investigate systemic, metabolic disease. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2009
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