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Post-operative pain behavior in rats is reduced after single high-concentration capsaicin application
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SYSNO ASEP 0044589 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Post-operative pain behavior in rats is reduced after single high-concentration capsaicin application Title Pooperační bolest je snížena po jednorázové aplikaci capsaicinu o vysoké koncentraci u krys Author(s) Pospíšilová, Eva (FGU-C)
Paleček, Jiří (FGU-C) RID, ORCIDSource Title Pain. - : Lippincott Williams & Wilkins - ISSN 0304-3959
Roč. 125, č. 3 (2006), s. 233-243Number of pages 11 s. Language eng - English Country US - United States Keywords capsaicin ; TRPV1 ; surgical pain Subject RIV ED - Physiology R&D Projects GA305/06/1115 GA ČR - Czech Science Foundation (CSF) GD305/03/H148 GA ČR - Czech Science Foundation (CSF) GA309/03/0752 GA ČR - Czech Science Foundation (CSF) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) Annotation The aim of this study was to evaluate the role of TRPV1 receptor-containing nociceptors in the development of post-operative allodynia and hyperalgesia by their functional inactivation using a high-concentration intradermal injection of capsaicin in a rat plantar incision model. Paw withdrawal responses to mechanical and thermal stimuli applied on plantar skin were tested in animals treated with capsaicin or the vehicle. Our results show an important role of TRPV1-containing nociceptors in the development of post-surgical hypersensitivity and suggest that local, high-concentration capsaicin treatment could be used to reduce it Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2007
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