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Duplication, balancing selection and trans-species evolution explain the high levels of polymorphism of the DQA MHC class II gene in voles (Arvicolinae)

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    SYSNO ASEP0042520
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleDuplication, balancing selection and trans-species evolution explain the high levels of polymorphism of the DQA MHC class II gene in voles (Arvicolinae)
    TitleDuplikace, balancující selekce a trans-species evoluce vysvětlují vysoký stupeň polymorfismu genu DQA (MHC Class II) u hrabošů (Arvicolinae)
    Author(s) Bryja, Josef (UBO-W) RID, SAI, ORCID
    Galan, M. (FR)
    Charbonnel, N. (FR)
    Cosson, J.-F. (FR)
    Source TitleImmunogenetics. - : Springer - ISSN 0093-7711
    Roč. 58, 2-3 (2006), s. 191-202
    Number of pages12 s.
    Languageeng - English
    CountryDE - Germany
    KeywordsMuridae ; allelic diversity
    Subject RIVEB - Genetics ; Molecular Biology
    CEZAV0Z60930519 - UBO-W (2005-2011)
    UT WOS000236500700012
    EID SCOPUS33645453416
    DOI10.1007/s00251-006-0085-6
    AnnotationWe described the structure and diversity of exon 2 of the MHC class II DQA gene in three species of voles (Arvicolinae) exhibiting regular multi-annual fluctuations of population density and analysed the processes leading to the observed MHC polymorphism. All exon 2 sequences translate to give unique amino acid sequences and positive selection was found to act very intensively on antigen binding sites. We documented the presence of recombination at vole DQA region but its importance in generating allelic polymorphism seems to be relatively limited. For the first time with rodents, we documented the duplication of the DQA gene in all three species with both copies being transcriptionally active.
    WorkplaceInstitute of Vertebrate Biology
    ContactHana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
    Year of Publishing2007
Number of the records: 1  

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