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Duplication, balancing selection and trans-species evolution explain the high levels of polymorphism of the DQA MHC class II gene in voles (Arvicolinae)
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SYSNO ASEP 0042520 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Duplication, balancing selection and trans-species evolution explain the high levels of polymorphism of the DQA MHC class II gene in voles (Arvicolinae) Title Duplikace, balancující selekce a trans-species evoluce vysvětlují vysoký stupeň polymorfismu genu DQA (MHC Class II) u hrabošů (Arvicolinae) Author(s) Bryja, Josef (UBO-W) RID, SAI, ORCID
Galan, M. (FR)
Charbonnel, N. (FR)
Cosson, J.-F. (FR)Source Title Immunogenetics. - : Springer - ISSN 0093-7711
Roč. 58, 2-3 (2006), s. 191-202Number of pages 12 s. Language eng - English Country DE - Germany Keywords Muridae ; allelic diversity Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000236500700012 EID SCOPUS 33645453416 DOI 10.1007/s00251-006-0085-6 Annotation We described the structure and diversity of exon 2 of the MHC class II DQA gene in three species of voles (Arvicolinae) exhibiting regular multi-annual fluctuations of population density and analysed the processes leading to the observed MHC polymorphism. All exon 2 sequences translate to give unique amino acid sequences and positive selection was found to act very intensively on antigen binding sites. We documented the presence of recombination at vole DQA region but its importance in generating allelic polymorphism seems to be relatively limited. For the first time with rodents, we documented the duplication of the DQA gene in all three species with both copies being transcriptionally active. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2007
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