Number of the records: 1
Assembly of the 81.6 Mb centromere of pea chromosome 6 elucidates the structure and evolution of metapolycentric chromosomes
- 1.0584246 - BC 2024 RIV US eng J - Journal Article
Macas, Jiří - Robledillo, Laura Avila - Kreplak, J. - Novák, Petr - Koblížková, Andrea - Vrbová, Iva - Burstin, J. - Neumann, Pavel
Assembly of the 81.6 Mb centromere of pea chromosome 6 elucidates the structure and evolution of metapolycentric chromosomes.
PLoS Genetics. Roč. 19, č. 2 (2023), č. článku e1010633. ISSN 1553-7404. E-ISSN 1553-7404
R&D Projects: GA MŠMT(CZ) LM2018131
Institutional support: RVO:60077344
Keywords : genome * kinetochore * duplication * annotation * generation * alignment * sequence * provides * shows * gene
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 4, year: 2023
Method of publishing: Open access
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010633
Author summaryDespite their conserved function, centromeres exhibit considerable variation in their morphology and sequence composition. For example, centromere activity is restricted to a single region in monocentric chromosomes, but is distributed along the entire chromosome length in holocentric chromosomes. The principles of centromere evolution that led to this variation are largely unknown, partly due to the lack of high-quality centromere assemblies. Here, we present an assembly of the pea metapolycentromere, a unique type of centromere that represents an intermediate stage between monocentric and holocentric organizations. This study not only provides a detailed insight into sequence organization, but also reveals possible mechanisms for the formation of the metapolycentromere through the spread of centromeric chromatin and the accumulation of satellite DNA.
Permanent Link: https://hdl.handle.net/11104/0352322
Number of the records: 1