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STING 어댑터 단백질을 활성화하는 포스포네이트 결합을 가진 3'3' 사이클릭 다이뉴클레오티드

SYSNO ASEP	0582886
Document Type	P - Patent
R&D Document Type	Patent or other outcome protected by special legislation
Title	STING 어댑터 단백질을 활성화하는 포스포네이트 결합을 가진 3'3' 사이클릭 다이뉴클레오티드
Title	3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
Author(s)	Birkuš, Gabriel (UOCHB-X)_ORCID Páv, Ondřej (UOCHB-X)_{RID, ORCID} Jandušík, Tomáš (UOCHB-X)_ORCID Rosenberg, Ivan (UOCHB-X)_{RID, ORCID} Nencka, Radim (UOCHB-X)_{RID, ORCID}
Year of issue	2023
Possible third party use of the result	A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence
Royalty requested	A - Poskytovatel licence požaduje licenční poplatek
Patent no. or utility model no. or industrial design no.	KR102492187
Date of the patent acceptance	27.01.2023
Name of the patent owner	Ústav organické chemie a biochemie AV ČR, v. v. i
Code of the issuer name	KR001 - Korean Intellectual Property Office (KIPO) Daejeon Metropolitan City
Current use	A - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem
Territorial Protection	NEU - národní patent v zemi mimo EU PCT - mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci
Language	kor - Korean
Keywords	STING ; cyclic dinucleotide (CDN) ; cancer
OECD category	Organic chemistry
R&D Projects	EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UOCHB-X - RVO:61388963
Annotation	본 발명은 일반식 (J)의 3'3' 사이클릭 포스포네이트 다이뉴클레오티드, 이의 약제학적으로 허용가능한 염, 이를 포함하는 약학적 조성물, 및 상기 물질과 기타 의약제 또는 약제의 조합물에 관한 것이다. 본 발명은 또한 암, 바이러스성 질환, 알레르기성 질환 및 염증성 질환과 같은 STING 단백질 조절에 의해 변형가능한 질환 또는 병태를 치료 또는 예방하기 위한 상기한 화합물의 용도에 관한 것이다. 또한, 상기한 물질들은 백신에 보강제로서 사용될 수 있다.
Description in English	Provided herein are the 3'3' cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2024
Electronic address	https://worldwide.espacenet.com/patent/search/family/065244414/publication/KR102492187B1?q=KR102492187B1

Number of the records: 1