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2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
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SYSNO ASEP 0580601 Document Type P - Patent R&D Document Type Patent or other outcome protected by special legislation Title 2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein Author(s) Birkuš, Gabriel (UOCHB-X) ORCID
Páv, Ondřej (UOCHB-X) RID, ORCID
Jandušík, Tomáš (UOCHB-X) ORCID
Rosenberg, Ivan (UOCHB-X) RID, ORCID
Nencka, Radim (UOCHB-X) RID, ORCIDYear of issue 2023 Possible third party use of the result A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence Royalty requested A - Poskytovatel licence požaduje licenční poplatek Patent no. or utility model no. or industrial design no. EP3728282 Date of the patent acceptance 22.11.2023 Name of the patent owner Ústav organické chemie a biochemie AV ČR, v. v. i Code of the issuer name EPO_1 - European Patent Office Munich, The Hague, Berlin, Vienna, Brusselshttp://www.epo.org/ Current use A - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem Territorial Protection EPC - evropský patent podle Evropské patentové úmluvy
PCT - mezinárodní patentová ochrana dle Smlouvy o patentové spolupráciLanguage eng - English Keywords STING ; cyclic dinucleotide ; agonist OECD category Organic chemistry R&D Projects EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UOCHB-X - RVO:61388963 Annotation The present disclosure relates to 2′3′ cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2024 Electronic address https://worldwide.espacenet.com/patent/search/family/065244413/publication/EP3728282B1?q=EP3728282B1
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