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Trypanosomes as a magnifying glass for cell and molecular biology
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SYSNO ASEP 0579778 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Trypanosomes as a magnifying glass for cell and molecular biology Author(s) Lukeš, Julius (BC-A) RID, ORCID
Speijer, D. (NL)
Zíková, Alena (BC-A) RID, ORCID
Alfonzo, J. D. (US)
Hashimi, Hassan (BC-A) RID, ORCID
Field, Mark Christian (BC-A) ORCIDNumber of authors 6 Source Title Trends in Parasitology. - : Elsevier - ISSN 1471-4922
Roč. 39, č. 11 (2023), s. 902-912Number of pages 11 s. Publication form Print - P Language eng - English Country NL - Netherlands Keywords variant surface glycoprotein ; double-stranded-rna ; alternative oxidase ; sleeping sickness ; brucei ; mitochondria ; import ; localization ; degradation ; peroxisomes Subject RIV EA - Cell Biology OECD category Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology R&D Projects GA23-07674S GA ČR - Czech Science Foundation (CSF) GX23-06479X GA ČR - Czech Science Foundation (CSF) GA20-14409S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support BC-A - RVO:60077344 UT WOS 001099395600001 EID SCOPUS 85169898897 DOI 10.1016/j.pt.2023.08.004 Annotation The African trypanosome, Trypanosoma brucei, has developed into a flexible and robust experimental model for molecular and cellular parasitology, allowing us to better combat these and related parasites that cause worldwide suffering. Diminishing case numbers, due to efficient public health efforts, and recent de-velopment of new drug treatments have reduced the need for continued study of T. brucei in a disease context. However, we argue that this pathogen has been instrumental in revolutionary discoveries that have widely informed molec-ular and cellular biology and justifies continuing research as an experimental model. Ongoing work continues to contribute towards greater understanding of both diversified and conserved biological features. We discuss multiple examples where trypanosomes pushed the boundaries of cell biology and hope to inspire researchers to continue exploring these remarkable protists as tools for magnifying the inner workings of cells. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2024 Electronic address https://www.sciencedirect.com/science/article/pii/S1471492223001952?via%3Dihub
Number of the records: 1