PEGylated poly(lactic-co-glycolic acid) nanoparticles doped with molybdenum-iodide nanoclusters as a promising photodynamic therapy agent against ovarian cancer

Verger, A.; Dollo, G.; Brandhonneur, N.; Martinais, S.; Cordier, S.; Lang, Kamil; Amela-Cortes, M.; Kirakci, Kaplan

doi:https://dx.doi.org/10.1039/d3ma00206c

Number of the records: 1

PEGylated poly(lactic-co-glycolic acid) nanoparticles doped with molybdenum-iodide nanoclusters as a promising photodynamic therapy agent against ovarian cancer

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SYSNO ASEP	0573899
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	PEGylated poly(lactic-co-glycolic acid) nanoparticles doped with molybdenum-iodide nanoclusters as a promising photodynamic therapy agent against ovarian cancer
Author(s)	Verger, A. (FR) Dollo, G. (FR) Brandhonneur, N. (FR) Martinais, S. (FR) Cordier, S. (FR) Lang, Kamil (UACH-T)_{SAI, RID, ORCID} Amela-Cortes, M. (FR) Kirakci, Kaplan (UACH-T)_{SAI, RID, ORCID}
Source Title	Materials Advances. - : Royal Society of Chemistry Roč. 4, č. 15 (2023), s. 3207-3214
Number of pages	8 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	cluster complexes ; polymer
Subject RIV	CA - Inorganic Chemistry
OECD category	Inorganic and nuclear chemistry
R&D Projects	GA21-11688S GA ČR - Czech Science Foundation (CSF)
	8J20FR008 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	UACH-T - RVO:61388980
UT WOS	001023678700001
EID SCOPUS	85165306265
DOI	10.1039/d3ma00206c
Annotation	Photodynamic applications requires efficient intracellular uptake of the photosensitizer that can be achieved through the development of nanoscaled delivery system. Herein, we prepared PEGylated poly(lactic-co-glycolic acid) nanoparticles doped with an octahedral molybdenum cluster complex bearing iodine inner ligands and o-carborane carboxylate apical ligands. This complex is a potent red luminophore and singlet oxygen photosensitizer under UV/blue-light irradiation, making it an attractive theranostic tool for photodynamic therapy and emerging modalities such as X-ray-induced photodynamic therapy or boron neutron/proton capture therapy. However, its hydrophobicity hinders its use in biological application and requires its encapsulation in nanocarriers. The nanoparticles, prepared using the solvent displacement method, displayed ideal properties in terms of size and zeta potential as a drug delivery system and exhibited a robust colloidal stability in biological medium, without the need of additional surfactant. The encapsulated complexes conserved their efficient red luminescence and singlet oxygen photosensitizing activity, while being protected from the detrimental hydrolysis process generally observed for this type of complexes in aqueous media. Evaluation of the in vitro biological activity of the nanoparticles against the ovarian cancer cell line SKOV-3 evidenced efficient uptake into the cellular membrane and cytoplasm and intensive phototoxic effect associated with an appreciable therapeutic window, suggesting potential as a photodynamic therapy agent against ovarian cancer.
Workplace	Institute of Inorganic Chemistry
Contact	Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931
Year of Publishing	2024
Electronic address	https://hdl.handle.net/11104/0344467

Number of the records: 1