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Mitochondria on the move: Horizontal mitochondrial transfer in disease and health
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SYSNO ASEP 0571547 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mitochondria on the move: Horizontal mitochondrial transfer in disease and health Author(s) Dong, L. (AU)
Rohlena, Jakub (BTO-N) RID, ORCID
Zobalová, Renata (BTO-N) RID
Nahácka, Zuzana (BTO-N)
Rodriguez, A. (FR)
Berridge, M. V. V. (NZ)
Neužil, Jiří (BTO-N) RIDNumber of authors 7 Article number e202211044 Source Title Journal of Cell Biology. - : Rockefeller University Press - ISSN 0021-9525
Roč. 222, č. 3 (2023)Number of pages 27 s. Language eng - English Country US - United States Keywords MESENCHYMAL STEM-CELLS ; MULTIPOTENT STROMAL CELLS ; TUNNELING NANOTUBES Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects GA20-05942S GA ČR - Czech Science Foundation (CSF) GX21-04607X GA ČR - Czech Science Foundation (CSF) GA22-34507S GA ČR - Czech Science Foundation (CSF) GA22-34507S GA ČR - Czech Science Foundation (CSF) NU22-08-00160 GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support BTO-N - RVO:86652036 UT WOS 000944268100001 EID SCOPUS 85148259890 DOI 10.1083/jcb.202211044 Annotation Jiri Neuzil and colleagues review the processes and mechanisms that underlie horizontal mitochondrial transfer (HMT) and the metabolic consequences of HMT in cells. Mammalian genes were long thought to be constrained within somatic cells in most cell types. This concept was challenged recently when cellular organelles including mitochondria were shown to move between mammalian cells in culture via cytoplasmic bridges. Recent research in animals indicates transfer of mitochondria in cancer and during lung injury in vivo, with considerable functional consequences. Since these pioneering discoveries, many studies have confirmed horizontal mitochondrial transfer (HMT) in vivo, and its functional characteristics and consequences have been described. Additional support for this phenomenon has come from phylogenetic studies. Apparently, mitochondrial trafficking between cells occurs more frequently than previously thought and contributes to diverse processes including bioenergetic crosstalk and homeostasis, disease treatment and recovery, and development of resistance to cancer therapy. Here we highlight current knowledge of HMT between cells, focusing primarily on in vivo systems, and contend that this process is not only (patho)physiologically relevant, but also can be exploited for the design of novel therapeutic approaches. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2024 Electronic address https://rupress.org/jcb/article/222/3/e202211044/213873/Mitochondria-on-the-move-Horizontal-mitochondrial
Number of the records: 1