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Neurogenesis as a Tool for Spinal Cord Injury
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SYSNO ASEP 0568846 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Neurogenesis as a Tool for Spinal Cord Injury Author(s) Havelíková, Kateřina (UEM-P)
Smejkalová, Barbora (UEM-P) ORCID
Jendelová, Pavla (UEM-P) RID, ORCIDArticle number 3728 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 23, č. 7 (2022)Number of pages 13 s. Language eng - English Country CH - Switzerland Keywords neurogenesis ; spinal cord injury ; ependymal stem cells ; astrocytes ; reprogramming ; spinal canal ; physical factors ; valproic acid ; growth factors ; neuroinflammation OECD category Neurosciences (including psychophysiology R&D Projects GA19-10365S GA ČR - Czech Science Foundation (CSF) EF15_003/0000419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000782089900001 EID SCOPUS 85127104010 DOI 10.3390/ijms23073728 Annotation Spinal cord injury is a devastating medical condition with no effective treatment. One approach to SCI treatment may be provided by stem cells (SCs). Studies have mainly focused on the transplantation of exogenous SCs, but the induction of endogenous SCs has also been considered as an alternative. While the differentiation potential of neural stem cells in the brain neurogenic regions has been known for decades, there are ongoing debates regarding the multipotent differentiation potential of the ependymal cells of the central canal in the spinal cord (SCECs). Following spinal cord insult, SCECs start to proliferate and differentiate mostly into astrocytes and partly into oligodendrocytes, but not into neurons. However, there are several approaches concerning how to increase neurogenesis in the injured spinal cord, which are discussed in this review. The potential treatment approaches include drug administration, the reduction of neuroinflammation, neuromodulation with physical factors and in vivo reprogramming. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2023 Electronic address https://www.mdpi.com/1422-0067/23/7/3728
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