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LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug
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SYSNO ASEP 0564801 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug Author(s) Cutano, Valentina (UOCHB-X) ORCID
Ferreira Mendes, Jessica Marianne (UOCHB-X)
Escudeiro-Lopes, Sara (UOCHB-X)
Machado, Susana (UOCHB-X) ORCID
Vinaixa Forner, Judith (UOCHB-X)
Gonzalez-Morena, Juan Manuel (UOCHB-X) ORCID
Převorovský, M. (CZ)
Zemlianski, V. (CZ)
Feng, Y. (CN)
Králová Viziová, Petra (UMG-J)
Hartmanová, Andrea (UMG-J)
Malčeková, Beata (UOCHB-X)
Jakoubě, Pavel (UOCHB-X) ORCID, RID
Iyer, S. (US)
Kečkéšová, Zuzana (UOCHB-X) ORCIDArticle number e202201510 Source Title Life Science Alliance. - : Life Science Alliance
Roč. 6, č. 1 (2023)Number of pages 15 s. Language eng - English Country US - United States Keywords mesenchymal transition ; lipid metabolism ; fallopian tube OECD category Biochemistry and molecular biology R&D Projects GJ18-24473Y GA ČR - Czech Science Foundation (CSF) EF19_074/0016322 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2018126 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF18_046/0015861 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UOCHB-X - RVO:61388963 ; UMG-J - RVO:68378050 UT WOS 000918610800003 EID SCOPUS 85141974169 DOI 10.26508/lsa.202201510 Annotation Epithelial-mesenchymal transition (EMT) is a cellular mechanism used by cancer cells to acquire migratory and stemness properties. In this study, we show, through in vitro, in vivo, and 3D culture experiments, that the mitochondrial protein LACTB manifests tumor suppressor properties in ovarian cancer. We show that LACTB is significantly down-regulated in epithelial ovarian cancer cells and clinical tissues. Re-expression of LACTB negatively effects the growth of cancer cells but not of non-tumorigenic cells. Mechanistically, we show that LACTB leads to differentiation of ovarian cancer cells and loss of their stemness properties, which is achieved through the inhibition of the EMT program and the LACTB-dependent down-regulation of Snail2/Slug transcription factor. This study uncovers a novel role of LACTB in ovarian cancer and proposes new ways of counteracting the oncogenic EMT program in this model system. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2024 Electronic address http://doi.org/10.26508/lsa.202201510
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