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Acid-Responsive Nanoporphyrin Evolution for Near-Infrared Fluorescence-Guided Photo-Ablation of Biofilm
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SYSNO ASEP 0562057 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Acid-Responsive Nanoporphyrin Evolution for Near-Infrared Fluorescence-Guided Photo-Ablation of Biofilm Author(s) Yang, M. (KR)
Özdemir, Zülal (UEB-Q) ORCID
Kim, H. (KR)
Nah, S. (KR)
Andris, Erik (UOCHB-X) ORCID
Li, X. (CN)
Wimmer, Zdeněk (UEB-Q) RID, ORCID
Yoon, J.-N. (KR)Number of authors 8 Article number 2200529 Source Title Advanced Healthcare Materials. - : Wiley - ISSN 2192-2640
Roč. 11, č. 14 (2022)Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords acid-responsive nanoporphyrin ; MRSA biofilms ; NIR fluorescence ; phototherapy ; structural evolution OECD category Organic chemistry R&D Projects FV10599 GA MPO - Ministry of Industry and Trade (MPO) EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Research Infrastructure e-INFRA CZ - 90140 - CESNET, zájmové sdružení právnických osob Method of publishing Limited access Institutional support UEB-Q - RVO:61389030 ; UOCHB-X - RVO:61388963 UT WOS 000797225500001 EID SCOPUS 85130269732 DOI 10.1002/adhm.202200529 Annotation Combating biofilm infections remains a challenge due to the shield and acidic conditions. Herein, an acid-responsive nanoporphyrin (PN3-NP) based on the self-assembly of a water-soluble porphyrin derivative (PN3) is constructed. Additional kinetic control sites formed by the conjugation of the spermine molecules to a porphyrin macrocycle make PN3 self-assemble into stable nanoparticles (PN3-NP) in the physiological environment. Noteworthily, near-infrared (NIR) fluorescence monitoring and synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) effects of PN3-NP can be triggered by the acidity in biofilms, accompanied by intelligent transformation into dot-like nanospheres. Thus, damage to normal tissue is effectively avoided and accurate diagnosis and treatment of biofilms is achieved successfully. The good results of fluorescence imaging-guided photo-ablation of antibiotic-resistant strains methicillin-resistant Staphylococcus aureus (MRSA) biofilms verify that PN3-NP is a promising alternative to antibiotics. Meanwhile, this strategy also opens new horizons to engineer smart nano-photosensitizer for accurate diagnosis and treatment of biofilms. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2023 Electronic address https://doi.org/10.1002/adhm.202200529
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