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Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis
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SYSNO ASEP 0557775 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis Author(s) Fořtová, A. (CZ)
Hönig, Václav (BC-A) RID, ORCID
Palus, Martin (BC-A) RID, ORCID
Salát, Jiří (BC-A) RID, ORCID
Pychova, M. (CZ)
Krbková, L. (CZ)
Vyhlídalová, Tereza (BC-A) ORCID
Kříha, M. (CZ)
Chrdle, A. (CZ)
Růžek, Daniel (BC-A) RID, ORCIDNumber of authors 10 Article number 001743 Source Title Journal of General Virology. - : Microbiology Society - ISSN 0022-1317
Roč. 103, č. 5 (2022)Number of pages 7 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords virus rna ; chemokines ; identification ; infection ; diagnosis ; cxcl10 ; tick-borne encephalitis ; neurofilament ; brain injury ; biomarker ; flavivirus Subject RIV EE - Microbiology, Virology OECD category Virology R&D Projects GA20-14325S GA ČR - Czech Science Foundation (CSF) GA20-30500S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support BC-A - RVO:60077344 UT WOS 000798232700001 EID SCOPUS 85129429737 DOI 10.1099/jgv.0.001743 Annotation Extensive axonal and neuronal loss is the main cause of severe manifestations and poor outcomes in tick-borne encephalitis (TBE). Phosphorylated neurofilament heavy subunit (pNF-H) is an essential component of axons, and its detection in cerebrospinal fluid (CSF) or serum can indicate the degree of neuroaxonal damage. We examined the use of pNF-H as a biomarker of neuroaxonal injury in TBE. In 89 patients with acute TBE, we measured CSF levels of pNF-H and 3 other markers of brain injury (glial fibrillary acidic protein, S100B and ubiquitin C-terminal hydrolase L1) and compared the results to those for patients with meningitis of other aetiology and controls. Serum pNF-H levels were measured in 80 patients and compared with findings for 90 healthy blood donors. TBE patients had significantly (P<0.001) higher CSF pNF-H levels than controls as early as hospital admission. Serum pNF-H concentrations were significantly higher in samples from TBE patients collected at hospital discharge (P<0.0001) than in controls. TBE patients with the highest peak values of serum pNF-H, exceeding 10000 pg ml(-1), had a very severe disease course, with coma or tetraplegia. Patients requiring intensive care had significantly higher serum pNF-H levels than other TBE patients (P<0.01). Elevated serum pNF-H values were also observed in patients with incomplete recovery (P<0.05). Peak serum pNF-H levels correlated positively with the duration of hospitalization (P=0.005). Measurement of pNF-H levels in TBE patients might be useful for assessing disease severity and determining prognosis. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2023 Electronic address https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001743
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